血管内皮生长因子和抑癌基因P33ING1与胃癌生物学行为的关系_医学论文.docVIP

血管内皮生长因子和抑癌基因P33ING1与胃癌生物学行为的关系_医学论文 血管内皮生长因子和抑癌基因P33ING1与胃癌生物学行为的关系_医学论文 【关键词】 血管内皮生长因子类；P33ING1；胃肿瘤；免疫组织化学 　　Relationship of vascular endothelial growth factor and p33ING1 with biological behaviors of gastric carcinoma 　　【Abstract】 AIM: To study the expressions of vascular endothelial growth factor(VEGF) and P33ING1 in gastric carcinoma, and their relations to the clinicopathological features. METHODS: VEGF protein and P33ING1 protein expressions in 102 cases of human gastric carcinoma tissues and normal tissues around the foci were examined by using immunohistochemistry. RESULTS: The expression of VEGF was high in carcinoma tissues while low in normal tissues(χ2=68.0, 0.01), as for P33ING1, the patter was contrary(χ2=40.3, 0.01). The expression of VEGF was related to serosa invasion, TNM stage, lymph node metastasis and 5year survival rate (0.05). There was a close relation between the expression of P33ING1 and tumor location, serosa invasion, TNM stage, lymph node metastasis and 5year survival rate (0.05). CONCLUSION: VEGF and P33ING are positively correlated with biological behaviors of gastric carcinoma, suggesting that examination by using immunohistochemistry for VEGF and P33ING1 may be of value in making diagnosis, evaluating evolution of disease in patients with gastric carcinoma at the same time. 　　【Keywords】 vascular endothelial growth factors p33ING1 stomach neoplasm immunohistochemistry 　　【摘要】 目的： 研究血管内皮生长因子（vascular endothelial growth factor, VEGF）和抑癌基因P33ING1蛋白表达与胃癌临床特征之间的关系. 方法： 采用免疫组化法检测102例胃癌患者手术切除的癌组织和癌周正常组织中VEGF 和P33ING1表达水平. 结果： VEGF在正常组织中呈高表达，在肿瘤组织中呈低表达，两者比较差异有统计学意义（χ2=68.0, 0.01）；P33ING1在正常组织中呈高表达，在肿瘤组织中呈低表达，两者比较差异有统计学意义（χ2=40.3, 0.01）. VEGF蛋白表达水平与胃癌浆膜浸润、TNM分期、淋巴结转移、5 a生存率有关(0.05)，P33ING1蛋白表达水平与胃癌肿瘤部位、浆膜浸润、TNM分期、淋巴结转移、5 a生存率有关(0.05). 结论: VEGF与P33ING1的表达和胃癌生物学行为有关，同时进行VEGF与P33ING1免疫组化法检测对胃癌患者病情判断和预后评价有一定的临床意义.　　【关键词】 血管内皮生长因子类；P33ING1；胃肿瘤；免疫组织化学 　　0引言 　　胃癌是我国人群中常见的消化道恶性肿瘤之一，其死亡率高居恶性肿瘤死亡率前几位，然而有关胃癌发生发展确切的分子机制仍不十分清楚，其中血管生长因子及抑癌基因的影响倍受关注. 血管内皮生长因