对生物可吸收聚乙丙交酯体外降解特性和强度维持的研究.pdfVIP

·540· 对生物可吸收聚乙丙交酯体外降解特性和强度维持的研究 王菲1，周洪1，王小鹏2，邹敏1 [摘要] 目的研究聚乙丙交酯(PmA)棒体外降解特性和强度维持，评估其作为可吸收正畸支抗种植钉材料的可行性。方 变化不大，随后质量减少加速；粘均分子量在降解的前12周下降较快，随后降解速度减慢；降解的24周内，弯曲强度和剪切强 度均大于骨皮质强度。结论固态压缩法制成的PI．GA棒具有较高的初始力学强度和强度维持时间，PLGA有望应用于可吸 收正畸支抗种植钉的研制。 [关键词]聚乙丙交酯；降解；生物可吸收 [中图分类号]R783．1[文献标识码】A [文章编号】1003．9872(20呕)10-0540-03 M珊妇勋rb日bIe in咖 Studyof山翟阳捌∞肼叫perti荡andstrengm她te删∞of polyglycolidelac2ide To the and retentionof vitroandtoevaluatethe Absgiact．Objectivestudydegradation strength properties polyglycolidelactide(PLGA)in ofPGLAusedasamaterialofbioabsorbableorthodontical invitroofPBS feasibility anchorage experiment implant．MethodsByhydrolyzing of were rate，the molecularand observed The of WaSh’t solution，weightlessnesschange weightstrengt}1 ch,锄seweight periodically．Results evident thefwst24weeksandthenthe decreased thefirst12weeksandthenit during ch趴seaccelerated；molecularweight during quickly 24 of the weeks andshear were thanhumancorticalbone．ConclusionPIX；A slowlydecreased；during aes,_adatio．，bendingst肥ngthhigher made had thatPGLA stick solid-state method mechanicalanda timeof by compression high str；ength long str】eIlgIllretention．It哪hopeful usedas of couldbe amaterialbioabsorhableorthodontical anchorageimplant． K眄words：pelyglycolidelactide；degradation；bioab∞rption 生物降解材料聚乙丙交酯(乳酸一乙醇酸) 1．2体外降解实验 nll