过氧化物酶体增殖物激活受体γ配体噻唑烷二酮类在脑缺血中的神经保护作用.pdfVIP

过氧化物酶体增殖物激活受体γ配体噻唑烷 二酮类在脑缺血中的神经保护作用 刘瑞光 毕桂南 [摘要] 噻唑烷二酮类物质为过氧化物酶体增殖物激活受体 γ(peroxisomeproliferator-activated receptorγ，PPARγ)的合成配体。PPARγ对多种类型组织均有一定的保护作用，研究涉及的领域包括 糖及脂类代谢、癌症、动脉粥样硬化等。目前，噻唑烷二酮类物质在中枢神经系统疾病中的作用备受 关注，如脑梗死、多发性硬化、阿尔茨海默病等。文章综述了脑缺血后PPARγ配体噻唑烷二酮类对抑 制神经胶质细胞增殖、促进血管生成以及对抗神经元凋亡的作用。 过氧化物酶体增生物激活受体γ；噻唑烷二酮类；噻二唑类；脑缺血；神经保护药 Neuroprotectiveeffectsofperoxisomeproliferators-acfivatedreceptorγ ligandthiazolidinedionesincerebralischemia LIURui-guanBIGui-nan DepartmentofNeurology.theFirstAffiliatedHospitalofGuangxiMedicalUniversity,Nanning530021,China [Abstract] Thiazolidinodionesareasyntheticligandofperoxisomeproliferator-activatedreceptorγ (PPARγ).PPARγhascertainprotectiveeffectsforseveraltypesoftissues.Theresearchcoverstheareasof glucose,lipidmetabolism,cancerandatherosclerosis,etc.Atpresent,therolesofthiazolidinedionesincentral nervoussystemdiseaseshavereceivedmuchattention,suchascerebralinfarction,multiplesclerosis,andAlzheimers disease.ThisarticlereviewstheeffectsofPPARγ ligandthiazolidinedionesoninhibitingtheproliferationofglial cells,promotingangiogenesis,andantagonizingneuronalapoptosisaftercerebralischemia. PPARγ;Thiazolidinediones;Thiadiazoles;BrainIschemia;NeuroprotectiveAgents 103760/cma.j.issn:1673-4165.2012.05.011 广西自然科学基金(0832133) 作者单位：530021南宁，广西医科大学第一附属医院神经内科 regulatedkinase，ERK）是MAPK家族成员之一，而活 因此推测TZD不能促进eNOS基因表达[5副，而是通 @@ [1] SalomoneS.Pleiotropiceffectsofglitazones:adoubleedgesword? FrontPharmacol,2011,2:14. @@ [2] SunH,YuX,WuHQ,etal.ThePPARγagonstrosiglitazone preventscognitiveimpairmentbyinhibitingastrocyteactivationand oxidativestressfollowingpilocarpine-inducedstatusepilepticus. NeurolSci,2012,33:559-566. @@ [3] LeeCH,ParkOK,YooKY,etal.Theroleofperoxisomeproliferator activatedreceptor γ,andeffectsofitsagonist,rosiglitazone,ontransient cerebralischemicdamage.JNeurolSci,2011,300:120-129. @@ [4] Kaun