选择性神经离断咬肌神经动物模型的建立_医学论文.docVIP

选择性神经离断咬肌神经动物模型的建立_医学论文 选择性神经离断咬肌神经动物模型的建立_医学论文 作者：杜本军，柳大烈，苏冰，梁莉，刘玉生，郑键生 【关键词】 咬肌 　　Establishment of animal model of selectively denervated masseter in rabbits 　　【Abstract】 AIM: To design and establish the animal model of selectively denervated masseter, in order to provide experimental data and theoretical evidence for clinical surgery. METHODS: In a total of 105 experimental rabbits 5 rabbits were selected for masseter and nerve anatomy, and the others were randomly devided into 4 groups: Normal control group and 3 experimental groups (denervation of masseter nerve stem, of superior division of masseter nerve, and of inferior division of masseter nerve). In experimental groups, every rabbit served as its own control, that was, the right side was experimental side, and the left side was control side. The animal modle of selectively denervated masseter was established, and the thickness and weight of experimental masseter were compared with the normals by the examination of B type ultrasound and electron equiarmbalance.RESULTS: After the masseteric nerve hed been abscised, the thickness or weight of denervated masseter obviously became thinner or lighter. The thickness and weight of experimental masseter was changed to 50.77% and 54.01% of the normals in group A, to 75.97% and 75.93% in group B , to 79.11% and 77.08% in group C. CONCLUSION: The animal model of selectively denervated masseter had been successfully set up for the first time. The thickness and humid weight of denervated masseter changed differently after different nerves were selected to be abscised. So, the model was available and credible, and was adapted to be used in researching denervated masseter in rabbits. 　　【Keywords】 masseter muscle denervation ultrasonography disease models, animal 　　【摘要】 目的： 设计及建立选择性失神经咬肌的动物模型，为临床外科提供实验资料和理论依据. 方法： 实验兔子共计105只，选取5只剥离咬肌，仔细解剖咬肌及神经，以明确其走行. 再将其余动物随机平均分为4组，1个正常对照组，3个试验组（离断咬肌神经干组、离断咬肌神经上分支组和离断咬肌神经下分支组），每只动物做自身对照，均以右侧咬肌为试验侧，左侧咬肌为对照侧. 建立选择性失神经咬肌动物模型，并行超声检测、质量测量，比较肌肉