Logistic Regression III- Advanced topics.pptVIP

Logistic Regression III: Advanced topics  Conditional Logistic Regression for Matched Data Recall: Matching Matching can control for extraneous sources of variability and increase the power of a statistical test. Match M controls to each case based on potential confounders, such as age and gender. If the data are matched, you must account for the matching in the statistical analysis!! Recall: Agresti example, diabetes and MI Match each MI case to an MI control based on age and gender. Ask about history of diabetes to find out if diabetes increases your risk for MI. Conditional Logistic Regression The Conditional Likelihood: each discordant stratum (rather than individual) gets 1 term in the likelihood Recall probability terms: ?The conditional likelihood= Conditional Logistic Regression Example: MI and diabetes Conditional Logistic Regression In SAS… proc logistic data = YourData;model MI (event = Yes) = diabetes;strata PairID;run; Could there be an association between exposure to ultrasound in utero and an increased risk of childhood malignancies? Previous studies have found no association, but they have had poor statistical power to detect an association. Swedish researchers performed a nationwide population based case-control study using prospectively assembled data on prenatal exposure to ultrasound. Example:Prenatal ultrasound examinations and risk of childhood leukemia: case-control study BMJ 2000;320:282-283 535 cases: all children born and diagnosed as having myeloid leukemia between 1973?and 1989?in Swedish registers of birth, cancer, and causes of death. 535 matched controls: 1 control was randomly selected for each case from the Swedish Birth Registry, matched by sex and year and month of birth. Each term in the likelihood represents a stratum of 1+M individuals More complicated likelihood expression! Just as easy to implement in SAS as we’ll see Wednesday… Ordinal Logistic Regression Ordinal Logistic Regression What if your o