壮族高血压患者胰岛素抵抗和洛伐他汀的干预研究_临床医学论文.docVIP

壮族高血压患者胰岛素抵抗和洛伐他汀的干预研究_临床医学论文 壮族高血压患者胰岛素抵抗和洛伐他汀的干预研究_临床医学论文 作者：黄照河，陆克兴，李天资，蓝景生，潘兴寿，黄显南，潘征，谭志辉 【摘要】 　　目的 探讨壮族高血压患者胰岛素抵抗(IR)情况及洛伐他汀对其干预效果。方法 将120例入选研究者分为单纯高血压组、高血压伴代谢综合征（MS）组和健康对照组，各40例，于早上8：00～9：00空腹测量血压、抽血检测空腹血糖（FPG）、空腹胰岛素（FINS）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C），然后口服75g葡萄糖粉2h后抽血检测餐后2h血糖（2hPG）和餐后2h胰岛素（2hINS），计算胰岛素抵抗指数（HOMA-IR）。纯高血压组和高血压伴MS组者予每日洛伐他汀20mg治疗8周后空腹抽血查FPG、FINS、TC、TG、HDL-C、LDL-C、VLDL-C。结果 纯高血压组2hPG、FINS、2hINS、HOMA-IR、TC、TG、HDL-C、LDL-C及VLDL-C明显高于对照组（0.01或0.05），高血压伴MS组2hPG、FINS、2hINS、HOMA-IR、TC、TG、HDL-C、LDL-C及VLDL-C明显高于纯高血压组和对照组（0.01或0.05），纯高血压组FBG与高血压伴MS组和对照组比较差异无显著性（Pgt;0.05），而高血压伴MS组FBG高于对照组（0.05）。予洛伐他汀治疗8周后除FPG、HDL-C外其余各项指标均有明显下降（0.01或0.05）。结论 壮族高血压患者存在IR，且伴有糖、脂代谢紊乱，洛伐他汀能有效降低其血脂水平，改善IR。 【关键词】 高血压；壮族；胰岛素抵抗；血糖；脂类/ 血液；洛伐他汀 　　Abstract: Objective To explore the insulin resistance in patients with hypertension from Zhuang nationality and the efficacy of lovastatin intervention. Methods 120 participants were randomly divided into hypertension group, hypertension associated metabolic syndrome (MS) group and healthy control group, 40 in each groups. Fasting blood pressure was measured at 8:00 to 9:00am, and blood samples were collected for detecting fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein (LDL-C), very low density lipoprotein-cholesterol (VLDL-C). 2h plasma glucose (2hPG) and 2h insulin (2hINS) were measured 2 hours after patients receiving 75gram glucose powder orally, the HOMA-IR was calculated. Hypertension group and hypertension associated MS group received lovastatin 20 mg daily for 8 weeks. FPG, FINS, TC, TG, HDL-C, LDL-C, VLDL-C were measured after drug administration. Results 2hPG, FINS, 2hINS, HOMA-IR, TC, TG, HDL-C, LDL-C and VLDL-C for hypertension group increased significantly than those for control group (0.01 or 0.05). 2hPG, FINS, 2hINS, HOMA-IR, TC, TG, HDL-C, LDL-C and VLDL-C for hypert