尿畅舒胶囊对绝经后尿道综合征尿流动力学的影响_临床医学论文.docVIP

尿畅舒胶囊对绝经后尿道综合征尿流动力学的影响_临床医学论文 尿畅舒胶囊对绝经后尿道综合征尿流动力学的影响_临床医学论文 【摘要】 目的 观察尿畅舒胶囊对肾虚血瘀型绝经后尿道综合征患者膀胱充盈期尿流动力学指标的影响。方法 采用随机对照、双盲双模拟的方法,选取肾虚血瘀型绝经后尿道综合征患者36例,分为尿畅舒胶囊治疗组(24例)和尼尔雌醇对照组(12例),分别给予尿畅舒胶囊及尼尔雌醇片治疗8周,观察治疗前后各组患者膀胱容量、膀胱顺应性等膀胱充盈期尿流动力学指标的变化。结果 治疗组及对照组患者最大膀胱容量、初始尿意容量、膀胱顺应性等膀胱充盈期尿流动力学指标较治疗前均有明显改善,差异有统计学意义(P＜0.05)。治疗组和对照组比较,差异无统计学意义(P＞0.05)。结论 尿畅舒胶囊治疗肾虚血瘀型绝经后尿道综合征,能有效增加患者膀胱容量,提高膀胱顺应性,降低膀胱敏感性,疗效与尼尔雌醇相仿。 【关键词】 尿畅舒胶囊；肾虚血瘀；绝经后尿道综合征；膀胱充盈期；尿流动力学 Abstract：Objective To investigate the effect of Niaochangshu capsule on urodynamics in bladder filling period of patients with post-menopause urethral syndrome of renal deficiency and blood stasis type. Methods A total of 36 patients with post-menopause urethral syndrome of renal deficiency and blood stasis type were randomly assigned to two groups：the trial group (24 patients were treated with Niaochangshu capsule) and the control group (12 patients were treated with Nilestriol). All patients were treated for 8 weeks. The changes of the urodynamic indexes in bladder filling period (the capacity of the bladder, the compliance of the bladder and the sensitivity of the bladder) were compared between the two groups. Results After treatment, the urodynamic index, including the maximum cystic capacity, the volume at the first desire to void and the cystic compliance were evidently improved in both of the trial group and the control group (P＜0.05). There was no statistical difference between the two groups (P＞0.05). Conclusion Niaochangshu capsule is effective in treating the patients with post-menopause urethral syndrome of renal deficiency and blood stasis type. It can increase the cystic capacity and compliance, step down the sensitivity of the bladder. Its effect is similar to Nilestriol. Key words：Niaochangshu capsule；renal deficiency and blood stasis；post-menopause urethral syndrome；bladder filling period；urodynamics 绝经后尿道综合征(post-menopause urethral syndrome)是指绝经后妇女因卵巢功能衰退,体内雌激素水平下降,引起膀胱、尿道组织变化而出现的以尿频、尿急、尿痛、排尿困难等下尿路症状为主要表现的一组症候群[1]。该病是绝经后