药物化学66477.pptVIP

药物化学 1. 磷酸二酯酶抑制剂类强心药－1 8.1.3.2 Calcium sensitizers 8.2.1 Calcium antagonists (Calcium channel blockers) Class of calcium antagonist 二氢吡啶类 Dihydropyridines, DHP 芳烷基胺类 Aralkylamines 苯并硫氮杂卓类 Benzothiazepines 二苯基哌嗪类 Diphenylpiperazines 二氢吡啶类钙拮抗剂－1 二氢吡啶类钙拮抗剂－3 SAR of Dihydropyridine 硝苯地平 Nifedipine 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester Clinically for the prevention and treatment of coronary heart disease,heart angina, anti-hypertension, but not for anti-arrhythmic. 8.2.1.2 Arylalkylamines ---calcium antagonists Metabolism of Diltiazem