邻苯二甲醛消毒剂合成工艺研究学士学位论文.docVIP

专科生毕业论文(设计) 邻苯二甲醛消毒剂合成工艺研究 摘 要 邻苯二甲醛(O-phthaleldehyde,简写为OPA),以前是一种重要的医药化工中间体,该中间体在胺类生物碱、荧光计组胺测定及医药检测方面有广泛的应用,而作为消毒剂应用的报道最早见于1994年,Alfa等通过评价OPA作为一种新型的高效消毒剂,与戊二醛相比,不仅具有光谱,高效和低腐蚀性的优点,还具有刺激性小,稳定性好等自身特点.且对耐戊二醛的龟分枝杆菌具有良好的杀灭作用. 邻苯二甲醛的合成路线较多,但大多产率较低,成本较高.本课题对邻苯二甲醛的合成路线进行了粗略的讨论. 以邻二(一氯甲基)苯为原料,在催化剂存在条件下与无水醋酸钠进行酯化反应,以氯化苯作为溶剂.分离有机相.有机相与水在碱性条件下进行水解反应,分离水相,减压蒸馏得邻苯二甲醇.以邻苯二甲醇为原料通过硝酸氧化得到目的产物邻苯二甲醛. 关键词:邻二(一氯甲基)苯；邻苯二甲醇；邻苯二甲醛 ABSTRACT OPA (O-phthaleldehyde, abbreviated as OPA), before the medicine is an important chemical intermediate, intermediate in the alkaloid amine, histamine fluorometer medical testing and determination of a wide range of applications, as Application of disinfectant found in the report as early as 1994, Alfa, and so on through the evaluation of the OPA as a new type of highly efficient disinfectant, glutaraldehyde, not only has the spectrum, high efficiency and low corrosive advantages, but also has a small irritation, stability Good, and so on its own characteristics. Glutaraldehyde and the resistance of Mycobacterium turtle has a good effect to kill. OPAs more synthetic route, but most of the low yield, the higher the cost. On the subject of the OPAs synthetic route to carry out the rough discussion. O-to (a chloromethyl) benzene as raw materials in the catalyst under the conditions of the existence of water and sodium acetate for esterification to lindane as a solvent. Organic phase separation. Organic phase and water in the alkaline conditions Hydrolysis, with water separation, vacuum distillation was the second o-methyl. OPA to methanol as raw materials have been adopted by the nitric acid oxidation product of the purpose of the OPA. Keywords: o-(a-methyl)-o-b methanol OPA 目 录 摘 要 II ABSTRACT III 1 邻苯二甲醛消毒剂的概况 1 1.1 对微生物的杀灭作用 1 1.2 杀菌机理 1 1.3 邻苯二甲醛消毒剂的特点 2 2 戊二醛消毒剂的优缺点 3 3 邻苯二甲醛现有合成工艺简介 4 4 论文选题的目的和意义 5 2.1 实验方案设计 7 2.2 实验试剂和仪器 7 3.1 引言 9 3.2 邻苯二甲醇的合成 9 3.3 合成原理 9 3.4 单因素试验设计 10 3.4.1 反应物质量的配料比对反应收率的影响 10 3.4.2 溶剂的量对反应的影响 11 3.5 正交实验设计 12 3.6 实验步骤 1