聊城大学硕士学位论文正文格式样本-2.doc

摘 要 在过去的二十年里，关于锑的羧酸衍生物的化学的研究已经成为一个活跃的领域，这不仅是因为锑的羧酸衍生物在结构上可以单节显性也可以超分子自组装，而且羧酸衍生物有很强的生物活性。研究结果表明，某些有机锑化合物对癌细胞的生长具有较强的抑制作用，比顺铂抗癌药物高100倍左右。故此，有机锑化合物的结构特征与抗癌活性的关系成了研究热点。而单晶X-射线衍射技术的开发和应用更使有机锑化学获得了空前的繁荣。根据所得到的微观结构信息，人们不仅对有机锑化合物的构效关系有了更直观的认识和更深入的了解，而且据此发现了有机锑化合物更为广泛的应用前景。因此对此类配合物的研究不仅在结构上有重要的意义，更重要的是其在合成、性质、生物活性等理论和应用等方面的研究。出于上述考虑，我们对有机锑羧酸衍生物的合成进行了系统研究，通过对产物的元素分析、利用红外光谱、核磁共振和X-射线单晶衍射等分析手段，确定生成物的组成和结构，并根据产物结构推测反应的过程和形成机理。主要工作有: 1. 三种有机锑卤化物:三苯基二氯化锑 (C6H5)3SbCl2、三苯基二溴化锑 (C6H5)3SbBr2和含氧桥的三苯基氯化锑 (C6H5)3ClSb-O-SbCl(C6H5)3。进行了X-射线单晶衍射结构分析。2. 利用三苯基二卤化锑与一元羧酸反应，得到了11个有机锑羧酸衍生物，利用元素分析、红外光谱和核磁共振谱对他们的性质进行了表征，对其进行了X-射线单晶衍射结构分析。结果表明:一元羧酸，特别是含的一元酸酸更易与三苯基二氯化锑形成单齿配位单节显性的化合物。有趣的是，化合物苯环上的氢原子易与杂原子形成氢键C-H…Cl、C-H…F、C-H…Br、C-H…O、C-H…π等，通过氢键作用形成二聚体、一维链、三维框架的超分子结构。………………………………………………………………………. 关键词有机锑化合物；羧酸衍生物；合成；X-射线单晶衍射；抗癌活性ABSTRACT The chemistry of organoantimony compounds derived from carboxylates have been an active area of research for more than two decades, not only for the striking structural possibilities ranging from discrete monomeric structures to supramolecular assemblies, but also for the biological importance in antimicrobial properties as well as antitumor activities. As a result of the deep research of organoantimony compounds, some can well inhibit the growth of cancer cell, even more active one hundred times than cis-platinum derivatives in antitumour activity. So it becomes a research hotspot on the relationship of the structure-effect of organoantimony compounds. With the development of X-diffraction technique and its application in structure chemistry, organoantimony chemistry boomed unprecedentedly. Based on these X-ray diffraction data, scientists are able to have a more intuitionistic observation and deeper perspective of the organoantimony compounds as well as to find more potential applications of the organoantimony compounds. Therefore studying these compounds has more meanings in synthesis, characterization, pharmaceutics and other theory and application researches oth