ω-3多不饱和脂肪酸对重症胰腺炎患者血清中C-反应蛋白的影响.docVIP

ω-3多不饱和脂肪酸对重症胰腺炎患者血清中C-反应蛋白的影响 　　作者：黄东, 刘丹, 屈振繁, 狄茂军,孙勤 作者单位：(郧阳医学院附属太和医院普外科，湖北 十堰 442000) 　　【摘要】目的：研究Ω-3多不饱和脂肪酸(PUFAs)对重症胰腺炎(SAP)患者C-反应蛋白(CRP)浓度变化的影响。方法:30例SAP患者，随机分为加用Ω-3多不饱和脂肪酸组(PUFAs组)及常规治疗组(对照组)，各15例，采用免疫散射比浊法检测入院后第1、3、7、14 d外周血中CRP浓度。结果：SAP患者加用PUFAs后外周血中CRP水平3 d内上升幅度较低，但3 d后下降幅度较高，均显著高于对照组(P 0.05)。结论：Ω-3 多不饱和脂肪酸能明显降低重症胰腺炎患者外周血中CRP水平，避免过度的炎症反应对机体器官组织的广泛损害,对提高SAP患者的临床治愈率、缩短疗程、提高疗效均具有重要意义。 　　【关键词】 Ω-3多不饱和脂肪酸;C-反应蛋白;重症胰腺炎 　　Effect of Ω-3 Polyunsaturated Fatty Acids on the Serum C-Reactive Protein in Severe Acute Pancreatitis Patients 　　HUANG Dong, LIU Dan, QU Zhen-fan，DI Mao-jun, SUN Qin 　　(Department of General Surgery ,Taihe Hospitol, Yunyang medical Collge，Shiyan,Hubei 442000,China) 　　Abstract: Objective To observe the effect of Ω-3 polyunsaturated fatty acids(PUFAs) on the serum C-reactive protein (CRP) in severe acute pancreatitis (SAP) patients. Methods Thirty SAP patients were divided into two group randomly: 15 patients were given PUFAs by peripheral veins (PUFAs group), and the other 15 patients (control group) were not given PUFAs. The serum CRP was measured by the immunoscattering assay at 1, 3, 7, and 14 day after the patients were admitted. Results The increasing level of CRP in PUFAs group was lower than that in the control group within the first 3 days, and its decreasing level was higher in PUFAs group than in control group after the third day(P0.05). Conclusion PUFAs could decrease significantly the serum CRP in SAP patients, and avoid the extensive tissue damage induced by the excessive inflammatory reaction, which had the important significance on the clinical healing rate, decreasing the period of treatment, and improving the effect of treatment for SAP patients. 　　Key words：Ω-3 polyunsaturated fatty acids; C-reactive protein; Severe acute pancreatitis 　　急性胰腺炎是常见的急腹症之一，病死率达22%[1]。早期准确判断病情和及时进行有效干预，对提高临床治愈率、缩短疗程、提高疗效均具有重要意义。本文通过观察15例应用Ω-3 多不饱和脂肪酸(PUFAs)治疗重症胰腺炎(severe acute puucreatictis, SPA)患者第1、3、7、14 d的血清C-反应蛋白