膝关节液中生物学标记物_型胶原羧基端端肽的检测及临床意义.pdfVIP

( ) 2008 42 2 Chin J Joint Surg( E lectron icV ersion), April 2008, Vol. 2, No. 2 45 李正南 卫小春 张志强 毕树雄 纪斌平 丁娟 王欢 !∀ ( CTX- ) ELISA 37 (, OA) 34( OA) CTX - , OuterbridgeA ral OA CTX - OA ( t= - 7 558, P 005) ; Ou terbridge #10 CTX- Outerbridge 10 ( t= - 7235, P 005); A ral # 60 CTX - A ral 60 ( t= - 5113, P 005); 71 CTX- Outerbridge ( r= 0743, P 005), A ral( r= 0706, P 005); OAOut erbridgeA ral ( r= 04 18, P 005); OA CTX- Outerbridge(r= 0533,P 005)A ral( r= 0 522, P 005) CTX- , ; CTX- !∀ ; ; M easurem ent and clinica l significance of CTX - level in synovia l fluid of the knees LI Zheng nan, WEIX iaochun, ZHANG Zhiqiang, BI Shuxiong, JI Binp ing, DING Juan, WANGHuan. Depart ent of Orthopaedics, SecondHosp ital, ShanxiM edical University, Taiyuan 030001, China !Abstract∀ Objective T o explore the relationsh ip of the CTX ( Ctelopeptide of t pe colla gen, CTX ) level in the s novial fluid of the knee w ith the degree of cartilage injur and s novitis. M ethods 37 patients w ith knee osteoarthritis ( OA group ), 34 patien ts w ith other knee d iseases ( nonOA group) w ere studied. The CTX level in the s novial fluid w as m easured b enz m e linked mi munoassa . The degree of cartilage injur w as assessed w ith Ou terbridge∃ s score s stem and the degree of s novitis w ith A ral∃ s score s stem under arthroscop . Results The results show ed that the CTX level in the s novial flu id of OA group w as h igher( t= - 7558, P 005) than that of non - OA group. The CTX level in the s novial flu id of the knees was higher in those w ith accum ulative Outerbridge∃ s score#10 than in thosew ith the score 10 ( t= - 7235, P 005). The CTX level in the s novial flu id of the knees w as h igher in those w ith A ral∃ s score # 60 than in those w ith the score 60 ( t= - 5113, P 005