缺氧相关蛋白碳酸酐酶-9 在结直肠癌的表达及生物学意义.pdfVIP

缺氧相关蛋白碳酸酐酶-9 在结直肠癌的表达及生物学意义 李　红 ，李　园 ，郗洪庆1 2 3 解放军总医院，北京　100853　 健康医学中心； 南楼消化科；病理科1 2 3 摘要 ：目的 评价缺氧相关蛋白碳酸酐酶 -9(CA-9) 在结直肠癌中的表达及与临床病理指标的可能关系。方法 采用免疫组 织化学方法检测 43 例结直肠癌 CA-9 的表达，并评价它们与病理分级、临床分期、转移之间的关系。结果 43 例结直肠癌 组织 CA-9 表达阳性 25 例，阴性 18 例。CA-9 的表达与结直肠癌肠壁浸润深度 (P=0.005)、淋巴结转移 (P=0.040)、肿瘤病 理分级 (P=0.047) 及临床分期 (P=0.002) 以及远处转移情况 (P=0.035) 密切相关。结论 CA-9 在转移组中的阳性表达率高，提 示可能是有效的预后因子。 关键词 ：结直肠肿瘤 ；肿瘤标记，生物学 ；CA-9 抗原 中图分类号 ：R 34　　文献标识码 ：Ａ　　文章编号 ：110124　　　　DOI: CNKI:11-3275/R1548.001 2011-03-18 15:48 网络出版时间：　　　　　　　　　　　　　　网络出版地址 ： Expression of hypoxia-related carbonic anhydrase-9 in colorectal carcinoma and its biological significance 1 2 3 LI Hong , LI Yuan , XI Hong-qing 1Center of Health Medicine, Chinese PLA General Hospital, Beij ing 100853, China; 2Department of Geriatric Gastroenterology, Chinese PLA General Hospital, Beij ing 100853, China; 3Department of Pathology, Chinese PLA General Hospital, Beij ing 100853, China Corresponding author: LI Hong. Email: lihongam @ Abstract: Objective To evaluate the expression of hypoxia-related carbonic anhydrase-9(CA-9) in colorectal carcinoma and its possible relation with clinical and pathologic indications of colorectal carcinoma. Methods Expression of CA-9 in 43 cases of colorectal carcinoma was detected with immunohistochemical method and its relation with pathological grade ，clinical stage, and metastasis of colorectal carcinoma was evaluated. Results The positive and negative CA-9 expression was in 25 and 18 cases of colorectal carcinoma, respectively. The CA-9 expression was closely related with the invasion depth (P=0.005), lymph node metastasis(P=0.040), histological grade(P=0.047), and clinical stage(P=0.002) of colorectal carcinoma. Conclusion The positive expression rate of CA-9 is high in metastatic colorectal carcinoma, indicating that CA-9 may be an effective prognostic factor for col