小剂量阿托伐他汀联合阿司匹林对脑_省略_粥样硬化斑块及血液生化指标的影响_夏菁.pdfVIP

2009 4 18 6 4 　ChinJCerebrovascDi,sApr.18, 2009, Vo.l6, No.4 ·189· · · 夏菁　周维智　刘晓红 :　 、 P (CD62P)、 GPⅡ b-Ⅲ a(PAC-1) C (hs-CRP) 。 　 104 、 1(34 )、 2 (32 ) (38)。 1 2 10、20 mg/d, 100 mg/d; 100 mg/d。 3 CD62P、 PAC-1、hs-CRP; 6。 　 1、2 : ①。②, 3 54、46、4 9 , 5、6、4 , 44、34、50 , 15、17、5 。 , , 。③, CD62 P、PAC-1 hs-CRP (P0.01), 。 (P0.01)。4.0 mmol/L, 1、2 2 1 , 7 14 (P0.05 )。。⑤ , 3 , 1 1, 2 0 。 2 6 (18.8%), 1 1(2.9%), (P0.05 )。 　 , 。 10 mg/d 20 mg/d 。 :　;;;P; GPⅡ b-Ⅲ a; C; do:i10.3969 /j.issn.1672-5921.2009.04.006 :　R743　　　 :　A Effectsoflow-doseatorvastatinincombinationwithaspirinoncarotidatheroscleroticplaquesand bloodbiochemicalparametersinpatientswithcerebralinfarction　XIAJing, ZHOUWe-izh,iLIU Xiao-hong.DeparmtentofNeurology, PutuoDistrictPeoplesHospita,lShanghai200060, China Abstrac:tObjective　Toobservetheeffectsoflow-doseatorvastatinincombinationwithaspirinon carotidatheroscleroticplaque,splateletssurfaceP-selectin(CD62 P), plateletglycoproteinⅡ b/Ⅲ arecep- torcomplex(PAC-1), andhighsensitivityC-reactiveprotein(hs-CRP)inpatientswithcerebralinfarc- tion. Methods　Atotal104 patientswithacutecerebralinfarctionwhosecarotidatheroscleroticplaques wereconfirmedbyultrasonographywererandomlyassignedintothreegroups:theinterventiongroup1 (n= 34 ), interventiongroup2 (n=32 )andthecontrolgroup(n=38).Patientsininterventiongroups1 and group2 receivedoralatorvastatin10 and20 mg/dseparately, andalsoreceivedBayaspirin100 mg/datthe sametim,ewhilethecontrolgrouponlyreceivedBayaspirin100 mg/d.TheplasmaCD62 P, PAC-1 and hs-CRPweredetected3 weeksaftertreatmen;tandthechangesofcarotidatheroscleroticplaquesandlipid wereexaminedwithultrasonographyat6 month.s Results　Ascomparedbetweenthe2 intervention group,sandthecontrolgroup:①Therewasnosignificantdifferenceinthesizeofcarotidatherosclerotic 　　:200060 ·190 · 20