老年脑梗死非急性期血清脂蛋白_a_和血浆纤维蛋白原含量的研究_张华.pdfVIP

2006888 ChinJ Geriatr Heart BrainVessel Dis,Aug 2006,Vol8, o.8 # 543 # ## (a) 张华, 张茁 ( , 100029) : 目的 研究老年脑梗死非急性期患者血清脂蛋白(a) [Lp(a) ] 和血浆纤维蛋白原(Fib) 的特点以及 互关系 方法 观察216例年龄大于65 岁的老年脑梗死非急性期患者( 脑梗死组) 和同期同年龄范围的211例无脑梗死的 老年患者( 对照组) , 测定Lp(a) 和Fib含量结果 脑梗死组患者的Lp( a)和Fib 含量明显高于对照组( P 0.01) , 脑梗死组患者Lp(a)含量和Fib 含量存在明显 关性( r = 0.204,P = 0.003) 结论 Lp( a) 和Fib均为老年脑梗死 患者患病的危险因素,两者存在的 关性提示在目前尚无可靠方法降低血清Lp(a) 的时候, 可以考虑通过降低血浆 Fib 浓度来达到老年患者脑血管病二级预防的目的 :脑梗塞; 脂蛋白类; 纤维蛋白原; 危险因素 :R743.33 :A : 1009-0126(2006)08-0543-03 Study on blood fibrinogen and lipoprotein(a) in the elderly with non-acute phase cerebral infarction ZHA GHua, ZHA G Zhuo ( Department of Neurology , Anz hen H osp ital of Capital University of Medical Sciences, Beji ing 100029, China) Abstract:Objectives To investigate theprofileof serum lipoprotein(a) [Lp(a)] and plasma fibrinogen(Fib) in the elderly with non-acute phase cerebral infarction, and to explore the relation between Lp(a) and fibrino- gen.Methods Two hundred and sixteen elderlywith non-acute cerebral infarction(CI group) were studied for the determination of serum Lp(a) and plasma Fib. Two hundred and eleven elderlywithout cerebral infarction were selected as control. Results CI group had significantly higher Lp( a) and Fib values ( P 0. 01) . Therewas positive correlation between Lp(a) and Fib( r = 0.204, P = 0. 003) . Conclusions Lp( a) and Fib arerisk factors of cerebral infarction in the elderly. Itwas possibleto reach the secondary prevention of ce- rebral infarction by lowering the plasma fibrinogen. Key words: cerebral infarction; lipoproteins;fibrinogen;risk factors ( a)