肠易激综合征患者食物不耐受临床研究.pdfVIP

30 2008 9 5 5 a a b 李汉华 , 韩盛玺, 董 巍 ( 四川省人民医院, a消化内科, b. 临床中心实验室, 四川成都 610072) 探讨食 不耐受在肠易激综合征( IBS)的发病与体液免疫的关系 对腹泻型 IBS 患者 50 例, 便秘型 IBS 患者 33例和健康对照组 25例, 采集外周静脉血, 应用酶联免疫方法, 半定量测定血清中 14种食 抗原的 特异性 IgG 抗体 食 特异性 IgG 抗体患者阳性率: 腹泻型 IBS 6600% ( 33 /50例), 便秘型 IBS 5152% ( 17 /33 例), 均高于对照组 1600% ( 4 /25例) (P 005); 腹泻型 IBS和便秘型 IBS比较差异无显著性意义( P 005) IBS 患者中多种食 IgG 抗体阳性者占 5400% 食 介导的体液免疫反应异常即食 不耐受在 IBS的发病机制中 具有重要的作用 肠易激综合征; 食 不耐受; 免疫球蛋白 G R5744 A 2008) Food intolerance study in subjects w ith irritab le bow el syndrom e LI H anh ua , H AN Sheng x ,i DON G We ( D ep artm en t of Gastroenterology, S ichuan Pro vinc ia l P eop le! s H osp ita l, S ichuan A cad emy of M ed ica l S ci ences, Ch engd u 6 10072, Ch ina ) A bstrac t O bjec tive To tudy the abnorm al humoral mi mune reaction after food intolerance, and to inve tigate the e tiology and mechan im of food intolerance in irr itab le bowel yndrom e ( IBS) M ethods T he pec ific IgG an tibod ie of 14 d iffer en t food antig en in erum w ere detected by the enzym e linked mi muno orbant a ay ( ELISA ) in 50 ca e of IBS w ith diarrhea, 33 ca e of IBS w ith con tipation and 25 normal control Re su lts The po itive rate of erum foodpec ific IgG antibodie w a 647 percent in IBS patient w ith diarrhea, 5151 percent in patient w ith con tipationBoth of them were h igher than that of norm al con trol ( P 005) Bu t there w a no ign ifican t difference betw een the two k ind of IBS patient Am ong the patient w ith po itive erum food pec ific IgG antibod ie , 5400 per