温和灸对高脂血症合并动脉硬化患者ADMANO的影响.pdfVIP

·492· Shanghai J Acu-mox, Jun 2014, Vol 33, No 6 文章编号:1005-0957(2014)06-0492-03 ·“973 计划”专栏· 温和灸对高脂血症合并动脉硬化患者ADMA、NO 的影响 阮佳伟1 1 2 2 ,张会芳,姜劲峰,王玲玲 (1.南京中医药大学,南京 210023;2.南京中医药大学针药结合重点实验室,南京 210023) 【摘要】 目的 观察温和灸在降血脂、抗动脉硬化的同时是否影响不对称二甲基精氨酸(asymmetric dimethylarginine, ADMA)。方法 采用病例序列研究,连续纳入符合高脂血症、动脉硬化标准的 17 例患者。温和灸神阙与双侧足三里,每穴施 灸 10 min,隔日 1 次。治疗前和治疗 6 星期、12 星期时分别检测血清 ADMA 和 NO 水平。结果 17 例患者中,治疗前 ADMA (35.41 ±12.68)µmol/L,治疗 6 星期时(29.57 ±12.12)µmol/L,较治疗前下降(P＜0.01),治疗 12 星期时(23.01± 7.0)µmol/L,较治疗前下降(P＜0.01),较治疗 6 星期时下降(P＜0.05);NO 治疗前水平(69.80±36.66)µmol/L,治疗 6 星期 (64.97±44.87)µmol/L,治疗 12 星期(36.48±27.87)µmol/L,较治疗前下降(P＜0.01)。结论 温和灸可显著下降高脂血症 合并动脉硬化患者血清ADMA 和NO 水平。 【关键词】 艾条灸;高脂血症;动脉硬化;一氧化氮;不对称二甲基精氨酸 【中图分类号】 R246.1 【文献标志码】 A DOI:10.13460/j.issn.1005-0957.2014.06.0492 Effect of Mild Moxibustion on ADMA and NO in Patients with Hyperlipidemia Complicated with Atherosclerosis RUAN Jia- 1 1 2 2 wei , ZHANG Hui-fang , JIANG Jin-feng , WANG Ling-ling . 1.Nanjing University of Chinese Medicine,Nanjing 210023, China; 2.Key Laboratory of Acupuncture and Medicine of Nanjing University of Chinese Medicine,Nanjing 210023,China [Abstract] Objective To observe whether mild moxibustion can affect asymmetric dimethylarginine (ADMA) when improving hyperlipidemia and atherosclerosis. Method According to the case series study design, 17 eligible patients with hyperlipidemia and atherosclerosis were recruited. They were given mild moxibustion at Shenque (CV8) and bilateral Zusanli (ST36), 10 min for each point, once every other day. The contents of serum ADMA and NO were determined before treatment, after 6-week and 12-week treatments respectively. Result Of the 17 patients, the content of ADMA was (35.41±12.68)µmol/L versus (29.57±12.12)µmol/L after 6-week treatment, and the