上海交大 生物化学 教材 上册习题答案.docVIP

Chapter 2 1. (a) tropomyosin原肌球蛋白 70-kd→ 35-kd (two-stranded)→ 318 residues (mean residue mass 110)→ 477?(axial distance of per residue in α-helix is 1.5?) (b)40 residues→ 36 (4 for hairpin turn) →18 (two-stranded) → 63? (the rise per residue 3.5? in βsheet) motif基序? mom基基t 2. contrasting isomer截然不同的异构体 dioxane二噁烷 in Leu methyl甲基 is attached to γ-C atom, while in Ile it to β-C atom(比较靠近主链α-碳原子,造成立体位阻,阻断α-螺旋的形成) 3. Ala　＜ Val; Ile ＞ Gly …Ala……Ile….. with activity (wild type) …Val……Ile…… lose activity (mutant type) …Val……Gly…