Analysis of Prognostic Factors for Surgery after Neo-adjuvant Therapy for Stage Ⅲ Non-small Cell Lung Cancer.pdfVIP

JHuazhongUnivSciTechnol[MedSci] DOI10．1007／sl1596—008—0614—7 28(6)：677．680．2008 677 AnalysisofPrognosticFactorsofrSurgeryafterNeo·adjuvant TherapyforStage．I．．．1l ． ． ．— — Non-smallCellLungCancer XuefengZHOU(周雪峰)，JianjunWANG(王建军)，JiashunWAN G(Y--g)l而)，YongchengPAN (潘永成)，JingsongLI(李劲松)， WendongWANG(汪文东)，FengZHAO(赵 峰) DepartmentofThoracicSurgery,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology, Wuhan430022，China Summary：In ordertoexplorethepossibilitytopredicttheriskfactorsforpostoperativecomplica— tionsandsurviva1time，theclinicaldataof152patients(including116malesand36females)who hadundergoneneo-adjuvanttherapyandsurgeryforstageⅡL andBnon—smal1celllungcancer (NSCLC)werere仃0spectivelvanalyzed．Demographicdata，preoperativefuncfionalparameters， staging inductionregimen(chemotherapyaloneorassociatedwithradiotherapy)．associateddisor— ders．anddataaboutoperationwerecollected．C —squraetestandmultivraiateanalysisfittingthe unconditionallogisticregressionmodelwereperofrmedtoidentifypredictorsofpostoperativecorn— plications．whileKaplan—M eierandmultivariateCoxproportionalhazradmodelwereemployedto identifypredictorsofsurviva1time．respectively．Theunivariateanalysisdemonstratedthatforced expiratory volumein 1secondpredictedpercentfFEVl％．P=O．o4o)andassociateddisorders (P=0．020)werethepredictivefactorsofcomplications．butmultivraiateanalysisfoundnoindepend— encefactors(尸0．05)ofit．UnivariateKaplan—Meieranalysisshowedthatstagef尸．=O．050)and pneumonectomyfP=0．018)affectedthesurvivaltime．Ho