高分子_纤维_负载手性氨基醇的合成及其催化二乙基锌对苯甲醛的不对称加成.pdfVIP

2006 26 Vol. 26, 2006 5 , 718722 Chinese Journal of Organic Chemistry No. 5, 718722 · · () *,a a a a b b (a 200444) (b 450052) , , , 34%, 9%. 5 . SEM , . (); ; ; Synthesis of a Polymer(fiber)-Supported Chiral Amino Alcohol and Its Application to Enantioselective Addition of Diethylzinc to Benzaldehyde LIN, Kun-Hua*,a ZENG, Qing-Bina LI, Ming-Xinga PAN, Qing-Yia SONG, Mao-Pingb WU, Yang-Jieb a ( Department of Chemistry, Shanghai University, Shanghai 200444) (b Department of Chemistry, Zhengzhou University, Zhengzhou 450052) Abstract A polymer(fiber)-supported chiral amino alcohol was synthesized and applied to the enantiose- lective addition of diethylzinc to benzaldehyde. Compared with the resin-supported chiral amino alcohol in the same reactive time, the fiber-supported amino alcohol could increase the yield and ee value by 34% and 9% respectively. This fiber-supported catalyst could be recycled more than 5 times. The reason why catalytic property was dropped down in recycle was proved to be the loss of catalyst by the analysis of their SEM photographs. Keywords polymer(fiber)-supported chiral amino alcohol; diethylzinc; benzaldehyde; enantioselective ad- dition ,