HIV致病机制研究进展李海英.pdfVIP

中 国 病 原 生 物 学 杂 志 2008 3 3 3 J our nal of P athog en B iology March 2008, Vol. 3, No. 3 227 HIV * 李海英, 吴昊 ( , 100069) , + , CD4 T , , ; , , , + HIV; ; ; CD4 T R373. 9 A 1673-5234(2008) 03-0227-04 [ J our nal of P athog en B iology . 2008 Mar; 3( 3) : 227- 230. ] Advances in pathogenesis of HIV I Hai-ying, WU Hao ( Youan H osp ital , Cap ital Univ er sity of M ed ical Sc iences , B eij ing 100069, Ch ina) Abstract The pathogenesis of chronic HIV- 1 infection has long been considered as chronic process of immune damage. However, recent studies suggest that the mechanisms ult imately resulting in AIDS initiate in the f irst weeks to months follow ing establishment of infection. During acute infection, the massive viral replication results in profound depletion of CD4+ effector memory T cells in extra-lymphoid interface tissues, severely damage the immune system and sets the stage of its eventual failure. In chronic H IV- 1 infection, general immune activat ion progressively disrupts the functional organi- zation of the immune system, damaging its regenerative capacity, ultimately leading to AIDS. + Key words H IV; AIDS; pathogenesis; CD4 T cell [5] ( HIV) + , ( AIDS)