ON THE ONTOLOGY OF DISEASE part II.ppt

ON THE ONTOLOGY OF DISEASE: part II the complexity dilemma complexity equivalence networksand the OBO foundry and the formation of a new network in biology biomedical theories of disease the humoral theory of disease the miasmatic theory of disease the germ theory of diseasethe modern era begins modern biomedicine in what do working biomedical scientists believe?is there a philosophy of biomedicine? the cell doctrine(proposed in 1838 by Matthias Schleiden and by Theodor Schwann) cells are the fundamental structural and functional units of all organisms all organisms are composed of one or more cells all cells come from preexisting cells all vital functions of an organism occur within cells cells contain the hereditary information necessary for regulating cell functions and for transmitting information to the next generation of cells in what do working biomedical scientists believe?is there a philosophy of biomedicine? traditional biomedicine the complexity dilemma restlessness in biomedicine the limitations of molecular mechanistic explanations mechanistic biochemical explanation recedes into the background MOVEMENT IN BIOMEDICINE TOWARDS A NEW PERSPECTIVE ON HEALTH AND DISEASE the omic entity omic levels of organization what does omic thinking add to biomedicine? beyond omics: the network intracellular organization NETWORKS IN BIOMEDICINE map of the C. elegans interaction network, or interactome, links 2,898 proteins (nodes) by 5,460 interactions (edges A Map of the Interactome Network of the Metazoan C. elegans. Science (2004) 303: 540 - 543. Graphical representation of a highly interconnected subnetwork TWO EXAMPLES OF RECENT RESEARCH STUDIES EXEMPLIFYING THE NEW APPROACH:GOING FROM MOLECULES TO CELLS TO ORGANISMS the universal nature of networks general network characteristics is a physics-biology link on the horizon? Sporn asks POSTSYNAPTIC DENSITY (PSD) the PSD The Pocklington study Modular structure and functional organization of the MASC (