基于复杂网络的时延基因调控网络构建.pdfVIP

11 V l. 38 N . 11 2010 11 ACTA ELECTRONICA SINICA N v. 2010 王雪松, 谷阳阳, 程玉虎 (, 221116) : , Laplace K , . , , , . , . : ; ; ; : TP391 : A : ( 2010) Construction of Delay Gene Regulatory Network Based on Complex Network WANG Xues ng, GU Yangyang, CHENG Yuhu ( School of I nf ormation and Electrical Engi neering , China Univers ity of Mining and Technol ogy , X uzhou , J iangs u 221116, China) Abstract: By using the analysis idea and meth ds f c mplex netw rk, we ad pted a n rmalized Laplace matrix and a K mean clustering meth d t detect multiple c mmunities in a gene regulat ry netw rk ( GRN) . At the same time, genegene interac ti ns b th inside a c mmunity and am ng c mmunities were als described. In additi n, in rder t reflect the actual genegene in teracti n pr cess and t impr ve the m deling precisi n f GRN, a timeseries spectrum analysis meth d was used t estimate delay f gene expressi n bef re the pr cess f c mmunity detecting. Experimental results f the cell cycleregulated genes f yeast sh w that the pr p sed c nstructi n meth d f GRN n t nly can reflect the actual genegene interacti n pr cess much exactly but als can pr vide details ab ut the gene regulat r m del. Key words: c mplex netw rk; delay; gene regulat ry netw rk; c mmunity ; , 1 , . [ 1] , , , . , , . , , , [ 2] [ 5, 6] . , K , [ 3] [ 4]