纳米银溶胶的研制.pdfVIP

专题( 医用高分子) Thematic Forum(Medical Polymer Materials) 技术 纳米银溶胶的研制 秀菊 赵成如 山东省医疗器械研究所 ( 济南 250100) 内容提要：目的：采用一条绿色、环保的途径合成纳米银溶胶。方法：以水溶性壳聚糖为胶体保护剂、还原剂及 络合剂，葡萄糖为促进剂，通过超声振荡的方法还原硝酸银合成了纳米银溶胶。对纳米银溶胶进行了 透射电镜TEM 的表征和紫外分光光度的扫描，通过调整水溶性壳聚糖、葡萄糖的比例、超声波的功 率、时间，以透射电镜测试结果为指标，确定了纳米银溶胶的最佳合成工艺。对纳米银溶胶的贮存稳 定性进行了考察，进行了纳米银溶胶的体外抗菌性能的研究。结果：当m :m :m = 10:5:1， 壳聚糖 葡萄糖 A gN O3 超声功率150W ，超声60m in时，所制备的纳米银溶胶的平均粒径在10nm 以下，且分布比较均匀，形 状为类球形；溶胶放置一年不聚集，较稳定。该纳米银溶胶体外抗菌性能测试结果表明对金黄色葡 萄球菌、大肠杆菌、白色念珠菌有很明显的抑菌圈，100m g.L- 1的纳米银溶胶的抑菌率都为100% 。结 论：该纳米银溶胶制备工艺切实可行，稳定可靠，体外抗菌试验为制剂提供了理论基础。 关键词： 纳米银 溶胶 工艺研究 抗菌性 Preparation and Evaluation of Nano-Silver Sol GOU Xiu-ju ZHAO Cheng-ru Shandong Medical Instrument Institute (Jinan 250100) Abstract: Objective: To study the nano-silver sol using green way. Methods : Taken the water-soluble chitin as the colloid protecting agent, the reducer and the complex agent, and the glucose as the promoter the AgNO3 was reduced to nano-silver sol through the supersonic vibration. The way of the synthesized nano-silver sol was green. The nano-silver sol was examined by TEM and the ultraviolet scanning. Through the adjustment of the ratio of the chitin and glucose to the AgNO and the ultrasonic wave power and 3 time, the optimal factors of the nano-silver sol were determined by the tested results of the TEM. The nano-silver sol’s stability had been carried on, and external antibacterial performance had been studied. Results : When the ratio of chitin, gluc