溶瘤腺病毒作为癌症基因治疗载体的研究进展及安全性评价.pdfVIP

网络出版时间：2013-08-14 09:52 网络出版地址：/kcms/detail/31.2035.Q0952.001.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(9): http ://www.cj DOI: 10.11844/cj cb.2013.09.0005 溶瘤腺病毒作为癌症基因治疗载体的研究 进展及安全性评价 何婉婉 周 立 刘 涛 阮江星 何滨霞 李阿荣 王毅刚* (浙江理工大学生命科学学院, 新元医学与生物技术研究所, 杭州310018) 摘要 腺病毒因具有易感染性、宿主范围广、毒性低、容纳量大、非整合性等特点而成为 基因转移中最具前景的基因载体之一, 并且被广泛地改造成各种类型的溶瘤腺病毒应用于癌症基 因治疗的研究之中。溶瘤腺病毒是目前基因治疗中最热门的研究途径之一, 其安全性也随之成为 另一个焦点问题。由此, 该文将对溶瘤腺病毒作为癌症基因治疗载体的研究进展及生物安全性评 价作一综述。 关键词 溶瘤腺病毒; 基因治疗; 安全性评价 Oncolytic Adenovirus as a Vector of Gene Therapy for Cancer Progression and Safety Evaluation He Wanwan, Zhou Li, Liu Tao, Ruan Jiangxing, He Binxia, Li Arong, Wang Yigang * (Xin Yuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China ) Abstract Adenovirus is one of the most promising gene vectors in gene transfer by the reason of susceptibility, wide host ranges, low toxicity, high capacity, non-integrated features and so on. Now it has been widely transformed into various types of oncolytic adenovirus in the study of cancer gene therapy. Oncolytic adenoviruses is one of the most popular avenues in the study of gene therapy so its safety has become another focus. This review focus on the overall research progress and biosafty evaluation of oncolytic adenoviruses as cancer gene therapy vectors. Keywords oncolytic adenovirus; gene therapy; safety evaluation 随着生命科学和医学研究的不断深入, 基因治 病毒, 包括腺病毒、反转录