人工神经网络在微丸片制备技术中应用.pdfVIP

人工神经网络在微丸片制备技术中的应用 1,2,3 1 1 1 1 1 1,2,3 潘昕 ，黄莹 ，黄心恬 ，李峰 ，吴晗 ，朱春娥 ，吴传斌* 潘昕：第一作者，讲师，研究方向为缓控释固体制剂，（专业：药剂学） 吴传斌：教授，博士生导师，研究方向为缓控释制剂，（专业：药剂学） 作者单位：1. 中山大学药学院； 2. 广东省创新药物制剂工程技术研究开发中心； 3.中山大学药物制剂工程研究开发中心 邮编：510006 联系人：潘昕 Email pxin_1385@163.com 摘要：目的采用粉体包合技术制备微丸片，将制备的微丸片与同处方常规 法制备的微丸片进行比较，证明粉体包合技术制备微丸片的优越性，同时考察人 工神经网络的预测能力。方法 以盐酸多西环素为模型药物，采用人工神经网络 设计微丸颗粒片和常规微丸片处方，并对制备的片剂进行质量检查。 结果 通 过实测数据和人工神经网络预测结果比较,验证了人工神经网络的预测能力。采 用粉体包合技术制备的微丸颗粒片f 2 值较同处方的常规微丸片高。 结论 人工 神经网络可以有效地对常规微丸片和微丸颗粒片的释药行为进行预测。粉体包合 技术制备的微丸颗粒，其表面的辅料层能够吸收压片过程中的压力，可以有效地 保护微丸衣膜在压片的过程中不发生破裂。 关键词：人工神经网络；微丸；微丸片；微丸颗粒片；缓控释制剂 Abstract: OBJECTIVE An novel method of the granulated pellets was introduced to prepare pellet-tablets. Then the two kinds of pellet-tablets were compared to validate the superiority of this novel pellet-tablets compaction technique. The prediction of Artificial Neural Networks (ANNs) was also evaluated in this article. METHODS Doxycycline hydrochloride was used as model drug, and ANNs was used for design the formulations of granulated pellet-tablets and pellet-tablets. RESULTE The predictive ability of ANNs was demonstrated according to the comparision of measured and verified data, and the f values of 2 granulated pellet-tablets were higher than the pellet-tablets. CONCLUSION ANNs could predict the behavior of drug release of granulated pellet-tablets and pellet-tablets effectively. The excipient layer of granulated pellets could absorb the compress force and protect the coating layer of pellets during compaction. Key words: Artificial Neural Networks; pellets; pellet-tablets; granulated pellet-tablets; sustained and controlled release 1. 引言 微丸片是上世纪八十年代被首次提出的一种新型缓控释制剂，它集合了