ibuprofentabletanditsmechanism：布洛芬片及其机制.pdfVIP

Journal of Scientific Industrial Research 550 J SCI IND RES VOL 66 JULY 2007 Vol. 66, July 2007, pp. 550-557 Studies on disintegrant action of Leucaena leucocephala seed gum in ibuprofen tablet and its mechanism P R P Verma* and Balkishen Razdan Department of Pharmaceutical Sciences, Birla Institute of Technology (BIT), Mesra, Ranchi 835 215 Received 26 December 2006; revised 30 March 2007; accepted 09 April 2007 Leucaena (Leucaena leucocephala) seed gum (LSG) was evaluated for disintegrant action in lactose (soluble) based tablets containing ibuprofen, a relatively insoluble drug. The properties of tablets evaluated include weight uniformity, hardness, friability, disintegration time and in vitro dissolution (k, T50, A30). LSG, at low concentration level (2% w/w), can be used as a disintegrant in tablet dosage form containing water-insoluble drug. In contrast to maize starch, LSG swells rapidly when brought in the contact with water, while preventing the liquid uptake in cylindrical column of powder. This presumably suggests that initial swelling of LSG particles generates enough pressure to elicit disintegration action in the tablet before further liquid uptake results in formation of mucilaginous, gel like coherent mass, which hinders further movement of water into the tablet matrix. Keywords: Disintegrant action, Ibuprofen, Leucaena leucocephala, Seed gum Introduction used for comparison of disintegrant profile. Minimum In pharmaceutical sciences, disintegration concentration, which can initiate