丝素蛋白作为组织工程生物材料的研究进展.pdfVIP

192 Chinese Journal of Reparative and Reconstructive Surgery, February 2008, Vol. 22, No.2 · · 丝素蛋白作为组织工程生物材料的研究进展 王宏昕 李敏 【摘 要】 目的 介绍丝素蛋白作为生物材料在组织工程应用中的研究进展及前景。 方法 广泛查阅国内外 关于丝素蛋白生物材料的研究文献，对丝素蛋白生物材料的性能及其在组织工程中的应用进行分析总结。 结果 丝素 蛋白具有生物降解性和生物相容性等特点，支持多种细胞的黏附、分化和生长，可应用于人工韧带、血管、骨、神经组织等 方面。修饰改性后的丝素蛋白可更好地应用于组织工程。 结论 丝素蛋白是一种良好的生物材料，在组织工程中有广 泛的应用前景。 【关键词】 丝素蛋白 组织工程 生物材料 研究进展 中图分类号：R318.08 Q813 文献标志码：A RECENT PROGRESS ON SILK FIBROIN AS TISSUE ENGINEERING BIOMATERIALS /WANG Hongxin, LI Min. College of Life Sciences, Fujian Normal University, Fuzhou Fujian, 350108, P. R. China. Corresponding author: LI Min, E-mail: mli@fjnu.edu.cn 【Abstract 】 Objective To summarize the latest developments in silk fibroin as biomaterials and its appl ications in tissue engineering. Methods The recent original l iterature on silk fibroin as biomaterials were extensively reviewed, illustrating the properties and appl ications of silk fibroin biomaterials in tissue engineering. Results Silk fibroin as biomaterials had good biocompatibility and degradability. It supported the cell adhesion differentiation and growth. It was used for artificial ligament, vessel, bone, nerve and so on. After modification, silk fibroin could be extensively used in tissue engineering. Conclusion Silk fibroin is a good biomaterial, which has a great potential applications in tissue engineering. 【Key words 】 Silk fibroin Tissue engineering Biomaterial Research progress Foundation items: National Natural Science Foundation of China; Development and Reform Commission （ ） Foundation of Fujian Province 2006-781 （ ） 组织工程的核心是建立由细胞和生物支架材料构 生物材料原料，具