急性白血病血清乳酸脱氢酶测定及其预后意义的研究.pdfVIP

中国医师杂志 　1999 年 3 月 　第 1 卷第 3 期 9 ·科研论著· 急性白血病血清乳酸脱氢酶测定及其预后意义的研究 ( ) 白求恩国际和平医院 050082 　　李栋梁 　宣宝和 解放军第二六零医院 　　　　　　张 　静 　　　　 ( ) ( ) 检测了 68 例初诊急性白血病 AL 患者血清乳酸脱氢酶 LDH 水平 ,并与部分 AL 的细胞核型、疗效及预后 进行了相关性分析。追踪观察了 21 例 AL 化疗前后的血清 LDH 变化。结果表明 : ⑴AL 的LDH 明显增高 ,其主 要来源于白血病细胞 ,可作为代表全身白血病细胞负荷的一项重要指标 ; ⑵化疗前 AL 血清 LDH 水平与完全缓 ( ) ( ) ( ) 解 CR 率、无病生存期 DFS 及总生存期 OS 有相关 ,提示它可作为 AL 疗效及预后判断的一项可靠参考指标 ; ⑶血清 LDH 在 AL 类型鉴别中的意义以及与细胞核型之间的确切关系尚待进一步研究。 关键词 　急性白血病 　乳酸脱氢酶 Measurement of Serum LD H and Its Prognostic Signif icance in Acute Leukemia L i D ong l iang , X uan B aohe. The Bethune International Peace Hospital ,ShiJiazhung 　050082 The activities of serum lactate dehydrogenase (LDH) in 68 cases with untreated acute leukemia (AL ) were de termined ,and the relationship among serum LDH level ,karyot ype ,therapeutical effect and pro gnosis was analysed. Serum LDH values before and after chemotherap y in 21 cases with AL were compared. The results showed that : ⑴ The serum LDH level was significantly increased in AL ,it main come from leukemic cells and may become a valuable marker of total body burden of leukemic cells. ⑵The serum LDH level in untreated AL was correlation with complete remission rate ,disease - free and total survival time. The data indicated that serum LDH activity may be a reliable pre dictor for chemotherapeutic effect and pro gnosis of AL . ⑶The exacting relations of serum LDH level with identifica tion of AL subsets and karyot ype need to be studied further.