温阳化瘀中药复方对2型糖尿病大鼠脂代谢及胰岛素抵抗的影响机制探讨_李小娟.pdfVIP

第 27 卷 第 12期 Vol. 27 N o. 12 2 0 09年 12月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Dec. 2 0 0 9 2 李小娟 (, 110032) : 目的:研究温阳化瘀中药复方对糖尿病大鼠体重甘油三 游离脂肪酸以及胰岛素敏感指数的影 响,探讨温阳化瘀中药复方改善胰岛素抵抗的机理材料和方法;用放射免疫方法测定空腹胰岛素; 用铜试剂显 色法测定游离脂肪酸 ( FFA ); 用酶法测定甘油三 (TG )胰岛素敏感指数以空腹血糖 ( FBG ) 与空腹胰岛素 ( FINS)乘积的倒数表示结论: 具有温阳健脾, 活血化瘀的中药复方能够减轻体重, 调整糖脂代谢, 降低血液粘 稠度, 从而达到改善胰岛素抵抗, 治疗糖尿病的作用, 为临床治疗肥胖的 2型糖尿病提供 一个思路 :糖尿病;肥胖; 脂代谢; 胰岛素敏感指数; 胰岛素抵抗 : R285. 5 : A : 1673- 7717( 2009) 12- 2617- 03 Effects ofWarming- yangDissolving- stasis Compound ChineseTraditionalM edicine (CCTM) on LipidM etabolism and Insulin Resistant in Type2 DiabetesM ellitusRats I X iao-juan ( The Affiliated Hospital of iaoning University of Traditional ChineseM edicine, Shenyang 110032, iaoning, China) Abstrac:t O bj ectiv e: Research the effect of warm ing- yang d issolving- stasis CCTM on body w eight, triglyceride (TG), free fatty acid ( FFA ) and insu lin sensitivity index in diabetic rats, to investigate the m echan ism ofw arm ing- yang dissolving- stasis CCTM mi proving insulin resistance.M ethod s: Fasting insu lin ( FINS) w as detected by Radiomi mu- noassay (RIA), FFA by calormi etric m ethod, and TG by enzym em ethod. Insu lin sensitivity index w as expressed by in- verse of the product of FBG and FINS. Conclusion: CCTM ofwarm ing- yang and invigorating spleen, activating blood and dissolving stasis cou ld losew eight, regu late glucose and lipidm etabolism, decreases the clotting of blood, to mi prove in- su lin resistant and treat diabetic. Itm aybe a new estway for treating obese type 2 diabetesm ellitus patients. Key w ords: d iabetesm ellitus; obesity; lip idm etabolism; insu lin sensitivity ind