肿瘤微环境中的免疫效应抑制.pdfVIP

27 2 V ol. 27 N o. 2 2006 4 In ternat ional Journal of P ath ology and C lin icalM ed icine A pr. 2007 * # # 胡多沙 综述 曹 亚 审校 中南大学肿瘤研究所, 长沙 4 10078) [ ] 肿瘤微环境内的免疫调节在肿瘤发生发展中具有重要功能 中多 个因素共同作用, 形成了肿瘤 局部免疫的特有模式肿瘤微环境中局部效应细胞功能障碍, 抑制性免疫调节细胞 T reg, 细胞因子的免疫负调节 作用, 抑制性配体受体反应以及肿瘤微环境中T 细胞代谢活性的负调节等参与了肿瘤微环境中的免疫效应抑制 [ ] 肿瘤免疫; 肿瘤微环境; 免疫抑制 [ ] R 73 [ ] A [] 1673-25 88 2007) 02-0108-04 Imm une effector phase suppression in tum or m icroenvironm en t HU Duo-sha, CAO Y a (Can cer R esea rch Institute, C en tral S outh University, Chang sha 4 10078, Ch ina ) [ Ab stract] Recently, advances have been m ade in the field of clarifying the m echan ism o f tum or patho logy in the background of tum or m icroenv ironm ent, w here anti-tum or mi mune effector phase has been greatly suppressed. In tum or m icroenv ironm ent, m any factors form ed the un ique pattern of the ant-i tum or mi m une effector phase. T cell dysfunction, T reg, inh ib itory ligands, and m etabolic dysregulation participate in mi m une effector phase suppression in tum or m icroenv irom ent. [ Key w ord s] ant-i tum or mi mune; tum or m icroenv ironm ent; mi m une suppression [ Int J Pathol C linM ed, 2007, 27 2) : 0108-04] + , ,