血清不对称性二甲基精氨酸浓度变化与慢性肾衰高血压相关性探讨.pdfVIP

2002, 27( 2) BULL HUNAN MED UNIV 133 1 1 2 3 1 1 张卫茹 , 陶立坚 , 陈本美 , 熊 燕 , 游运辉 , 陈立平 ( 1. 中南大学湘雅医院肾内科; 2. 中南大学湘雅医学院中心实验室; 3. 中南大学湘雅医学院药理教研室, 长沙410008) [ ] 采用高效液相色谱方法(HPLC) 检测29例血液透析 者血尿不对称性二甲基精氨酸( asymmetric dimeth ylargi i e, ADMA) 的浓度, 并与血压作相关性分析结果表明: 血液透析 者血清ADMA 浓度明显升高, 尿ADMA 浓度 降低, 与正常对照组比较差异有显著性( P 0.01) ; 血清ADMA 浓度与收缩压及舒张压呈明显正相关( 分别为r = 0. 634, P 0.01; r = 0. 735, P 0. 01) 结果提示血液透析 者体内ADMA 浓度增高, ADMA 的蓄积可能参与了慢性肾 衰高血压的病理生理过程 [ ] 血液透析; 不对称二甲基精氨酸; 高血压; 肾功能衰竭 [ ] R6925 [ ] A [ ] 2002) Relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure ZHANG Weiru, TAO Lijia , CHEN Be mei, et al . ( Dep artment of Nep hrology , X iangy a H osp ital , Central South University , Changsha 410008, China ) Abstract: Obj ective To i vestigate the relatio ship betwee serum asymmetric dimethylargi i e a d blood pressure i patie ts with chro ic re al failure. Methods We exami ed the levels of asymmetric dimethyl argi i e ( ADMA) i the serum a d uri e of 29 hemodialysis patie ts usi g the HPLC method, a d assessed the relatio ship betwee serum ADMA a d blood pressure. Results The level of serum ADMA was higher, but the level of uri ary ADMA was lower i the patie ts with chro ic re al failure tha those i the co trols. The serum ADMA was positively related to blood pressure. Conclusion The accumulatio of ADMA may be related to hy perte sio i patie ts with chro ic re al failure. Key words: hemodialysis; asymmetric dimethylargi i e; hyperte sio ; re al failure [ Bull Hu a Med U iv, 2002, 27( 2