西比灵治疗儿童偏头痛频繁发作的脑血流状态研究.pdfVIP

维普资讯 ． ● 中国疼痛医学杂志ChineseJournalofPainMedicine2006，12，(1 论 西比灵治疗儿童偏头痛频繁发作的脑血流状态研究 蔡 呜 马 强 (大连大学附属中山医院神经科，大连 116001) 摘要 目的：探讨西比灵治疗儿童偏头痛频繁发作的脑血流状态变化及临床意义。方法：应用经 颅多普勒超声技术(TCD)研究50例儿童偏头痛频繁发作患儿服药前及服药2周后脑血流改变及 头痛发作变化情况。结果：(1)30例一侧偏头痛患儿服药前头痛侧与非头痛侧大脑 中动脉 (MCA)、大脑前动脉(ACA)的收缩期峰值流速 (Vs)有显著性差异 (P0．01)，服药2周后双侧 MCA、ACA的Vs无明显差异 (P0．05)，非头痛侧服药前与服药2周后Vs无显著性差异(P0． 05)；(2)20例双侧偏头痛患儿服药前与服药2周后的Vs有显著性差异(P0．01)。结论：西比灵 能明显改善偏头痛患儿的脑血流指标，可减少偏头痛的发作次数和头痛程度。 关键词 西比灵；儿童偏头痛；脑血流 EFFECT OF SⅡlELIUM oN CEREBRAL BLOOD FLOW FOR CHILDREN W ITH FER - QUENTMIGRAD岖 CAIMing．MAQiang (DepartmentofNeurology，ZhongshanHospitalAffiliatedtoDalianUniversity，Dalian116001) Abstract Objective：Tostudytheeffectsofsibeliumoncerebralbloodflowforchildrenwithfrequent migraine，andtheclinicalsignificanceofsibelium inthetreatmentofchildrenmirgaine．Methods：Tran- scrnaialDopplerwascarriedoutin50childrenwithfrequentmirgainetoevaluatethecerebral arterialsys- tolicpeakbloodflowvelocity(Vs)pre-andpost-treatmentwithsibeliumfor2weeks．Results：(1) Comparedwiththenon-headacheside，30patientsofunilateralmigraineshowedsignificantdifference(P 0．01)inVsofmiddlecerebralartery(MCA)andanteriorcerebralartery(ACA)onheadacheside pre-treatment，nadshowednosignificantdifference(P0．05)anertwo-weektreatments．Therewasno singificnatdifference(P0．05)ofVsonthenon-headachesidebetweenpre-andpost-treatment．(2) 20patientsofbilateralmirgaineshowedsignificantdifference(P0．01)inVsofMCAnadACAbe- tweenpre-andpost-treatment．Conclusion：Sibelium callprofoundlyimprovethecerebral bloodflow and effectivelycontrolsymptomsoffrequentmirgaineinchildren． Keywords Childrenmirgaine；Sibelium；Cerebralbloodflow 偏头痛是儿童头