脑脉通对栓塞性脑缺血大鼠动脉溶栓治疗时间窗的影响.pdfVIP

2008 49 2 Journ l of T r dition l Chinese Medicine, 2008, Vol. 49, No . 2 163 1 2 3 1 1 1 1 李建生　王　冬　刘敬霞　郭晓燕　孙　捷　李　宁　苏　静 ( 1. 河南中医学院老年医学研究所, 郑州市金水路 1号, 450003; 2. 河南省洛阳市妇女儿童保健中心儿童医院; 3. 北京中医药 学) [ ] ( ) ( ) 3 6 9 24 , , , , , ; ; 6 ; , 3 6 9 ; , [ ] ; ; ; ; Effect of Naomaitong on the Time Window of Thrombolysis through Artery for the Cerebral Ischemic Rats with Thrombo-Embolism 1 2 3 - , , - , . LI Ji n sheng WA NG Dong LIU Jing xi et l ( 1. Ge r iatrics I nst itute of H e na n Univ e rs ity of T rad it ional Ch inese M e d icine, Z h engz h ou 450003; 2. W omen a nd Childr en Care Centr e of L uoy a ng City ; 3. B ei ing Un iv er sity of Chinese M ed ic ine) ABSTRACTObj ecti eT o study the protective effect nd influence of N om itong ( Remove obstruct ion of cerebr l vessels) on the tim e window of thromboly sis for the cerebr l ischemic r ts w it h t hrom bo-embolism. MethodsThe r t s w ere r ndomized into sh m-oper ted group, model group, urokin se ( UK) thromboly sis group, N om itong group, nd UK plus N om itong group ( ssoci ted group) . T he cerebr l ischemic r t m odels w it h thrombo-embolism w ere m de by blocking sylvi n rtery . The r ts were dministr ted loc l thromboly sis with duct to rtery t t he time-point of 3, 6, nd 9h fter cerebr l ischemi . At 24h of dm inistr - tion t hrough rtery, t he p thologic ch nges of br in nd the symptoms of nerve sy stem were observed to determine t he br in w ter r tio ( BWR) nd the ch nge of cerebr l inf rction re ( CIA) . ResultsComp red w ith the sh m-oper ted group, in ll model groups, t he score of nerve sy stem symptoms incre sed, the BW R nd CIA incre sed, nd the br in p thologi