氨酰-tRNA合成酶进化差异.pdfVIP

动 物 学 研 究 2007，Oct. 28 (5): 563－567 CN 53-1040/Q ISSN 0254-5853 Zoological Research 氨酰-tRNA 合成酶的进化差异 1, 2 1, 3,* 1650223 2. 1000493650223 摘要：-tRNA aaRS 关键词： -tRNA 中图分类号：Q523; Q349.5文献标识码：A 文章编号：0254-5853-(2007)05-0563-05 Evolutionary Diversities of Aminoacyl-tRNA Synthetases TANG Su-ni 1, 2, HUANG Jing-fei 1, 3,* (1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China; 2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China; 3. Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming 650223, China) Abstract: Studies show that the gene evolutionary mechanisms and modes, aminoacylation routes, and evolutionary mechanisms in structure and function of many aminoacyl-tRNA synthetases (aaRS), are diverse in some bacteria and eukaryotes. Thus, further studies on these diversities will be useful in understanding protein structural and functional evolution. Although the essential mechanism responsible for these diversities is not understood, these diversities suggest that certain aspects of the biological processes between bacteria and eukaryotes require further study. Key words: Aminoacyl-tRNA synthetase; Domain; Molecular evolution; Diversity 蛋白质结构与功能的关系是分子生物学的基 而成的蛋白质往往被认为是由功能类似或相同的 本问题之一，从细菌到真核生物的进化过程中，蛋 “祖先”分子演化而来。 白质的序列和结构都会有不同程度的变化，随着这 氨酰-tRNA 合成酶(aminoacyl-tRNA synthetase, 些变化，蛋白质的功能也会发生程度不同的变化。 aaRS)是蛋白质合成过程中的一类重要蛋白，通常 然而，蛋白质结构与功能在其分子进化中的这种变