6种血清肿瘤标志物联合检测对肺癌诊断临床价值.pdfVIP

Journa l of M ed ica l Forum V ol. 3 1 N o. 18 September 2010 ! 3! 6 * 1 1 刘 莹, 张 辉 , 张 筠 450052 比较 6种血清肿瘤标志物检测对肺癌诊断的临床价值 采用酶联 疫吸附试验法 检测 106例肺癌和 56 例肺良性疾病患者的血清神经元特异性烯醇化酶 ( N SE ) 细胞角蛋白 19 片段 ( Cy - fra21- 1) 恶性肿瘤生长因子( T SGF ) 糖类抗原 125( CA 125) 血清鳞状细胞癌抗原( SCC - Ag ) 癌胚抗原 ( CEA ) , 观察肿瘤标志物联合检测对肺癌的诊断价值 肺癌组 6种肿瘤标志物水平均显著高于肺良性疾 病组( P 均 005) ; 6种肿瘤标志物联合检测的灵敏度和准确度分别为 9 33% 873% , 均优于单项检测 肿瘤标志物联合检测可提高肺癌诊断的灵敏度和准确度, 有助于肺癌的诊断 肺癌, 肿瘤标志物, 诊断 R7 342 A ( 2010) 1800030 3 ClinicalValue of Six Kinds Serum TumorM arkers in Diagnosis of Lung Cancer LI U Ying, ZHANGH ui, ZHANG Yun TheFirstAff iliatedH osp ital of Zhengzhou University, Zhengzhou 450052, hina ABSTRACT Objecti e T o comp are the value of six k inds serum tumo r m arkers in d iagnosis o f lung cancer. M ethods EL ISA w as to detect six k inds serum tum or m arkers in 106 cases o f lung cancer and 56 p atientsw ith ben ign lung d isease, serum neuron- specific eno lase ( N SE ), and six k inds serum tum or m arkers w ere cytokeratin 19 fragm ent ( Cy fra2 1- 1) , tum or grow th facto r ( TSG F) , carbo hydrate ant igen 125 ( CA 125) , serum squ am ous ce ll carc inom a antigen ( SCC - A g) , carcinoem bryonic an tigen ( CEA ), to ob serve the va lu e of tum or m arkers in d iagnosis for lung cancer. T he level o f six k inds m arkers in lung cancer w ere sign if icantly higher than benign lung disease group ( P all 005), and Jo in t detection six kinds o f tum or m arkers in diagnosis sen sit iv ity and accuracy w ere 933% , 873% , w ere sup erior to sing le test. Conclusion T he tum orm arkers can mi prove the d iagno sis o f lung cancer sen sitiv ity