美沙拉嗪联合云南白药灌肠对溃疡性结肠炎患者的临床研究.pdfVIP

40 ·论 著 · July2012，Vo1．10，No．19 美沙拉嗪联合云南白药灌肠对溃疡性结肠炎患者的临床研究 容海鹰 杨元生 彭卫斌 朱雅丽 (广州新海医院，广东广州 510310) 【摘要】目的 观察美沙拉嗪联合云南白药灌肠对溃疡性结肠炎 (UC)的临床疗效。方法 42例UC患者随机分对照组和治疗组，每组21 例 ，前组予美沙拉嗪，后组予美沙拉嗪联合云南白药保留灌肠，观察患者治疗前后临床症状，血清c反应蛋白 (CRP)和肿瘤坏死因子-Ⅸ (TNF—a)，以及结肠的病理变化。结果 两组患者治疗后临床症状、血清CRP和 TNF—o【水平，以及结肠病理损伤均较治疗前均改善 ，治 疗组疗效更佳，总有效率为95．23％，与对照组比较有统计学意义 (76．2％，PO．05)。结论 美沙拉嗪联合云南白药保留灌肠对减轻UC 患者的炎性反应 ，改善临床症状和肠道病理损伤疗效显著，该疗法值得临床推广。 【关键词】溃疡性结肠炎；肿瘤坏死因子一o【；美沙拉嗪；云南白药；保留灌肠 中图分类号：R574．62 文献标识码 ：B 文章编号：1671—8194 (2012)19-0040-02 ClinicalResearch ofM esalazineCom binedwithYunnanbaiyaoPowderColoclysisonPatientswithUlcerativeColitis RONGHai—y撕g．YANG Yuan—sheng,PENG Wei—bin．ZHU Ya—li epartmentofGastroenterology,theSecondAffiliated (Xinhai)HospitalofGuangdongPharmaceuticalUniversity,Guangzhou，510310,Chin A『bstract]ObjecfiveToapproachtheclinicaleffectofmesalazinecombinedwithtraditionalchineseenemaonpateintswithulcerativecolitis (UC)． MethodsForty—twoUCpatientswererandomlydividedintoconrtolgroupandtreatmentgroup，21casesineachgroup，theformergroupwasaccepted mesalazinetherapy，thelatergroupwastreatedwithmesalazineandyunnanbaiyaopowderretention enema，theserum levelsofCreactiveprotein (CRP)andtumornecrosisfactor-a (TNF一0)【weretestedbyratencphelometryandelisarespectively,colonoscopyandcolontissueHEstainingwere undertookbeforeandaftertreatment．ResultsTheclinicalsymptomsrelief,serum CPR andTNF-Ⅱlevelsandcolonicpathologicaldamageswereimproved significantlyaftertreatmentintworgoups，thetotaleffectiveratewas95．23％ intreatmentrgoup，whichhadsignificantdifferencecomparingwithhtatin controlgroup(76．2％，P0．05)．ConclusionThetherapyofmesalazinecombinedwithyunnanbaiyaopowderretentionenemacaneffectivelylesson inflammation，reduceintestinalpahtologicaldamageandrelieveclinicalsymptomsofpatientswithUC，whic