靶向肽在递送siRNA进行肺癌治疗研究中的应用.pdfVIP

674 · · 中国肺癌杂志2 0 1 4 年 9 月第 1 7卷第 9 期 Chin J Lung Cancer, September 2014, Vol.17, No.9 DOI: 10.3779/j.issn.1009-3419.2014.09.06 · 综 述 · 靶向肽在递送siRNA进行肺癌治疗研究中的 应用 高红林 刘鉴峰 宋娜玲 【 】肺癌被认为是全球发病率最高的一种恶性肿瘤，其对化疗药物不敏感且易产生耐药性，因此增强肺 摘要 癌药物治疗效果是近年来研究的热点。siRNA是一种小RNA分子，可以沉默与之互补的目标mRNA ，是一种基因治 疗手段。靶向肽是一类小分子多肽，它可以与siRNA联合使用，利用其与肿瘤表面物质特异性结合发挥靶向作用。 联合靶向肽的特异性和siRNA 的治疗作用，增加siRNA在靶点位置的聚集，增强沉默效果，可以提高肺癌对药物的 敏感性并降低耐药作用，进而增强肺癌治疗效果，为肺癌的靶向治疗提供新的方向和策略。本文将对靶向肽在递送 siRNA进行肺癌治疗研究中的应用作一简要综述。 【关键词 】肺肿瘤； 靶向肽； siRNA Application of Target Peptide in siRNA Delivery for the Research of Lung Cancer Therapy Honglin GAO, Jianfeng LIU, Naling SONG Department of Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192, China Corresponding author: Jianfeng LIU, E-mail: Lewis78@163.com; Naling SONG, E-mail: nalingsong@ Abstract Lung cancer is considered a kind of malignant tumors of the world highest incidence. As it is not sensi- 【 】 tive to chemotherapy and easy to produce drug resistance, improving effect of anticancer drug becomes a research focus recent years. siRNA, small interfering RNA, can silence complemenary mRNA which is a kind of gene therapy. Target peptides are small molecular peptides which specifically bind to tumor surface materials. When used with siRNA, target peptides can in- crease accumulation