联合检测C反应蛋白与幽门螺杆菌在良恶性胃疾患诊断中的意义.docVIP

联合检测C反应蛋白及幽门螺杆菌在良恶性胃疾患诊断中的意义 　　作者：赵丽红,郭春林,王永福　　作者单位：包头医学院第一附属医院，内蒙古包头 　　【摘要】 目的:测定慢性胃炎、胃溃疡和胃癌患者血清中C反应蛋白(CRP)浓度水平结合有无幽门螺杆菌(HP)现症感染，探讨其变化的机理，为临床应用提供理论基础和实验依据。方法：对符合条件的慢性胃炎31例、胃溃疡30例、胃癌27例患者同时进行电子胃镜、13C-尿素呼气试验(13C-UBT)和血清CRP浓度的检测。结果：胃溃疡组血清CRP浓度水平(9.24 mg/L)高于慢性胃炎组血清CRP水平(2.89 mg/L)，差异有统计学意义(P0.05);胃癌组CRP水平(35.19 mg/L)高于慢性胃炎组及胃溃疡组，差异有统计学意义(P0.05)。慢性胃炎组与胃癌组HP检出率比较及胃溃疡组与胃癌组HP检出率比较差异均有统计学意义(P0.0125)。慢性胃炎组HP阳性血清中的CRP略高于HP阴性血清，但二者比较差异无统计学意义(P0.05);胃溃疡组HP阳性血清中的CRP高于HP阴性血清，差异有统计学意义(P0.05);胃癌组HP阳性血清中的CRP略高于HP阴性血清，但差异无统计学意义(P0.05)。结论：联合检测CRP及HP可以为临床医生提供更多的胃癌早期诊断的信息，而且还有助于对良恶性胃疾患的鉴别诊断;胃溃疡组CRP水平与有无HP现症感染有关，慢性胃炎组和胃癌组CRP水平与HP现症感染的关系还有待于进一步研究。 　　【关键词】 C反应蛋白,幽门螺杆菌,慢性胃炎,胃溃疡;胃癌 　　Abstract Objective：To study the diagnostic and discriminative role of serum C-reactive protein (CRP) and Helicobacter pylori (HP) in chronic gastritis，gastric ulcer or gastric cancer，to explore the changes in the mechanism to provide a theoretical basis for the clinical application. Methods: Electronic gastroscopy，13C-urea breath test (13C-UBT) and serum concentrations of CRP testing were carried out at the time of diagnosis. 31 cases of chronic gastritis，30 cases of gastric ulcer and 27 cases of gastric cancer were included in the study. Results: Mean serum CRP level of gastric ulcer group (9.24 mg/L)was higher than that of chronic gastritis group(2.89 mg/L) and the difference was significant (P0.05); mean serum CRP level in gastric cancer group(35.19 mg/L)was significantly higher than that of chronic gastritis group and gastric ulcer group (P0.05); Detection rate of HP between chronic gastritis group and gastric cancer group，and between gastric ulcer group and gastric cancer group were significantly different (P0.012 5); No significant difference was observed in mean CRP level of chronic gastritis group between HP positive serum and HP-negative serum (P0.05 ); mean CRP level of gastric ulcer group in HP positive serum was significantly higher than that in HP negative serum (P0.05);while mean CRP