·综述·子宫内膜癌化疗进展.pdfVIP

436 国际妇产科学杂志20 10 年12 月第37 卷第6 期 J Int Obstet Gynecol December 20 10 Vol. 37 No. 6 综 述 宫内膜癌化疗进展 晓燕综述 向 阳审校 揖摘 要铱 化疗是晚期或复发性子宫内膜癌的主要治疗方式遥 化疗在高危子宫内膜癌中的作用已引起 重视遥临床研究GOG209 将卡铂/紫杉醇渊carboplatin and paclitaxel TcP冤与子宫内膜癌标准化疗方案阿霉素/紫 杉醇/顺铂联合化疗渊doxorubicin paclitaxel and cisplatin TAP冤进行比较 其结果值得期待遥 放疗联合化疗可以 改善高危早期患者的生存遥 续贯化疗-放疗-化疗模式渊chemotherapy interval radiation and further chemothera鄄 py CRC 冤有利于改善晚期子宫内膜癌患者的生存遥 需重视化疗的毒副作用 序贯双联疗法渊卡铂/紫杉醇和卡 铂/阿霉素冤是一种降低药物毒性的策略遥 揖关键词铱 子宫内膜肿瘤曰抗肿瘤联合化疗方案曰 临床对照试验曰 治疗曰 药物疗法 Research Progress on Chemotherapy of Endometrial Carcinoma SHEN X iao-yan XIA NG Yang. Dep artment of Obstetrics and Gynecology Peking Union Medical College Hosp ital Peking Union Medical College Chinese A cademy of Medical Sc iences Beij ing 100730 China 揖Abstract 铱 Chemotherapy are the main treatment for advanced or recurrent endometrial cancer. The role of chemotherapy in the high-risk patient is currently the focus of the researchers. Among the current Gynaecologic Oncology Group 渊GOG 冤trials in endometrial cancer treatment GOG209 comparing carboplatin and paclitaxel 渊TcP 冤with the triplet of doxorubicin paclitaxel and cisplatin 渊TAP冤 is the most anticipated study and may be challenge the current standard regimen of TAP. Radiation plus chemotherapy significantly improved overall survival 渊OS冤 and progression- free survival 渊PFS冤 for patients with early endometrial cancer at high risk for micrometastases. Chemotherapy interval radiation and further chemotherapy 渊CRC 冤may be the most favorable sequence given in the improved overall survival in