卵巢癌患者血清CA125水平和临床分期病理类型的相关性研究.pdfVIP

56 I论 著 中国医药指南2010年6月第8卷 第l7期 GuideofChinaMedicine，June2010，Vo1．8，No．17 卵巢癌患者血清CA125水平与临床分期病理类型的相关性研究 孙荣华 摘【要】目的 探讨卵巢癌患者血清CA125水平与临床分期病理类型的相关性。方法 采用化学发光法检测了62例卵巢癌患者，47例卵巢良 性肿瘤患者，5O例健康对照者的血清CA125浓度。结果 卵巢癌患者血清CA125水平显著高于卵巢良性肿瘤组和健康对照组 O．O1)； 卵巢良性肿瘤组血清CA125水平明显高于健康对照组 (P0．05)；卵巢癌组患者 中，血清CA125水平与肿瘤分期之间有密切相关性，随着 临床分期的增加 ，血清CA125水平逐渐增加 ，不同临床分期的卵巢癌患者之间，血清CA125水平差异有显著性 O．01)；血清CA125 水平与卵巢癌病理类型之间亦有密切相关性，浆液性显著高于非浆液性 (P0．O1)。结论 卵巢癌惠者血清CA125水平与临床分期病理类型 均有密切相关性，血清CA125是卵巢浆液性囊腺癌的首选标志物，对治疗效果监测，判断有无复发、转移具有重要-I盏床价值。 【关键词】卵巢癌；CA125；临床分期；病理类型；化学发光 中图分类号：R737．31 文献标识码：B 文章编号：1671-8194(2010)17-0056-02 AnalysisoftheRelationshipbetweentheSerum CA125andClinicalStaging，PathoiogicalTypeof thePatientswith OvarianCarcinoma SUNRong-hua (TheSecondPeopleSHospitalofDezhou，Dezhou253004，Chin IAbstractlObjectiveToinvestigatetherelationshipbetweentheserumCA125andtheclinicalstage，pathologicaltypeofthepatientsofovarian carcinoma．MethodsMeasureatetheserumCA125withCLIAandmakeacomparisonamong62caseswithovariancarcinoma，47caseswithbenignovarian tumornad50healthypersons．ResultsComparingwiththevaluesofthepatientsofbening ovariantumorandhealthypersons，thevaluesofserumCA125 inhtepatientsofovariancarcinomawereobviouslyhigher(P0．01)．Comparingwithhealthypersons，thevaluesofserumCA125ofhtepatientsofbenign ovarina tumorwereobviouslyhigher O．05)inovariancarcinomacasesseurmCA125levelandutmorstagingshowpositivecorrelation．Whenstage rising，CA125levelisrising．TheCA125levelsweresignificantdifferencebetweenthedifferentstageofovariancarcinoma(P《O．O1)．SerumCAll25level andpahtologicaltypeshowcorrelation．SeurmCA125levelofserousutmorwasmuchhigherthantheseurmCA125levelofthenon-seroustumor仔．