3Department of Radiology 4Department of Anatomy and Neurobiology Running head Identificatio【荐】.pdfVIP

Articles in PresS. J Neurophysiol (March 26, 2003). 10.1152/jn.01040.2002 Identification of cerebral networks by classification of the shape of BOLD responses 12 1 134 Giovanni díAvossa , Gordon L. Shulman and Maurizio Corbetta Washington University, St. Louis, MO 63110 1Department of Neurology and Neurological Surgery 2Alzheimerís Disease Research Center 3Department of Radiology 4Department of Anatomy and Neurobiology Running head: Identification of cerebral networks Abstract 249 words, text 31 pages, 10 figures Contact: Giovanni díAvossa Alzheimers Disease Research Center Washington University School of Medicine 4488 Forest Park Ave., Suite 130 St. Louis, MO 63108 tel: 314-362-4541 fax: 314-362-6110 e-mail: davossag@neuro.wustl.edu Copyright (c) 2003 by the American Physiological Society. Abstract Changes in regional blood oxygen level dependent (BOLD) signals in response to brief visual stimuli can exhibit a variety of time-courses. To demonstrate the anatomical distribution of BOLD response shapes during a match to sample task, a formal analysis of their time-courses is presented. An event related design was used to estimate regional BOLD responses evoked by a cue word, which instructed the subject to attend to the motion or color of an upcoming target, and those evoked by a briefly presented moving target consisting of colored dots. Regional BOLD time-courses were adequately represented by the linear combination of three orthogonal waveforms. BOLD response shapes were then classified using a fuzzy clustering scheme. Three classes (sustained, phasic and negative) best characterized cue responses. Four classes (sustained, sustained-phasic, phasic and b