赤雹果多糖对免疫抑制小鼠免疫功能影响.pdfVIP

L ISH IZHEN MED ICINE AND MATER IA MEDICA RE SEARCH 2010 VOL. 21 NO. 7 2010 21 7 赵 波, 张玉玲, 佟继铭* (, 067000) : 观察赤雹果多糖对免疫抑制模型小鼠免疫功能的影响 采用环磷酰胺( CY)造模法制作小鼠免疫抑制 模型, 观察赤雹果多糖对实验动物免疫器官重量指数碳粒廓清能力迟发型变态反应 ( DTH)溶血素( IgM )含量的影响 - 1 赤雹果多糖 400, 200 m g kg 剂量组能显著提高小鼠免疫脏器指数单核巨噬细胞的吞噬功能及小鼠迟发型超敏 反应, 促进溶血素的生成 赤雹果多糖有显著提高免疫抑制小鼠免疫功能的作用 : 赤雹果; 多糖; 免疫功能; 环磷酰胺 DO I: o:i 10. 3969/ j. issn. 2010. 07. 025 : R285. 5 : A : 2010) Effects ofPolysaccharide from the Fruit ofTh lad ian tha dub ia Bunge on the Immunefunc tions of ImmunosuppressedM ice * ZHAO Bo, ZHANG Yuling, TONG J im ing (Institute of ChineseMateriaM edica, ChengdeM edical College, Chengde, H ebei 067000 China) Abstract:Objective To observe the effects of polysacchari e from the fru it ofThladianthadubia Bunge on the mi mune functions of mi m unosuppresse m ice. Methods Immunosuppresse m ouse m o el w as estab lishe by intraperitoneal injection w ith cyclo phospham i e follow e by aily intragastric a m in istration of polysacchari e from the fru it ofThladiantha dubia Bunge. After the treatm ent, the m ice w ere exam ine for mi m une organ weight in ex, carbon particle clearance capab ility of m acrophage, elaye type hypersens itivity, serum IgM level follow ing exposure to sheep erythrocytes. Results Treatm en t of the mi munosuppresse m ice w ith polysacchari e from the fru it ofThladiantha dubia Bunge at the aily ose of 400 an 200 m g kg- 1 sign ificantly increase the w eight of the mi m une organs, carbon particle clearance capab ility of m acrophage, elaye type hypersensitivity, serum IgM level against erythrocytes. onclusion The polysacchari e from the fru it of Thladiantha dubia Bunge can enhance the mi m une