Salicylic Acid Semisolid Preparations.ppt

Salicylic Acid Semisolid Preparations Faith White Advisors: Dr. Antoine Al-Achi Mrs. Janice Jackson-Freeman Objective The purpose of this experiment was to determine the distribution of salicylic acid in creams, ointments, and pastes. Key Terms Salicylic Acid Cream Ointment Paste Salicylic Acid(C7H6O3) Cream Viscous liquid or semisolid emulsions of either the oil/water(o/w) or water/oil (w/o) type. Examples: O/W type:shaving, hand, and foundation creams W/O type: cold and emollient creams Methods1. Preparation of Cream Ointment Semisolid preparations intended for the external application to the skin or mucous membranes; usually contain medicinal substances; properties vary. Methods2.Preparation of Ointment Paste Concentrates of absorptive powders dispersed (usually) in petrolatum or hydrophilic petrolatum. Often used in the treatment of oozing lesions. Are also used to restrict the area of treatment by acting as an absorbent. Methods3.Preparation of Paste Preparation of Diluted Alcohol 515 mL of 95% ethyl alcohol USP was measured using volumetric flask and graduated cylinder. 500 mL of deionized water was measured using volumetric flask. Ethyl alcohol and deionized water was combined for a 49% alcohol solution. Preparation of 0.1 N Sodium Hydroxide 8 grams of sodium hydroxide pellets was weighed and dissolved in deionized water and filled to 2 L mark on volumetric flask. Methods a. To 25 mL of diluted alcohol (49%), one drop of phenolphthalein TS and sufficient 0.1 N sodium hydroxide from a buret was used to produce a faint pink color. Amount of Salicylic Acid in Dosage Forms Results5. The precision of our preparations. Conclusion Due to inconsistencies in the data it was concluded that maybe there was not sufficient mixing time for the release of salicylic acid from the base... Acknowledgements I would like to thank Dr. Al-Achi for all of his help in completing this experiment and Mrs. Freeman for all of her guidance, time, and pa