Ras-MAPK通路在食管癌中的研究进展.pdfVIP

中国病理生理杂志 ChineseJournalofPathophysiology 2013，29(2)：376—380 [文章编号] 1000—4718(2013)02—0376-05 Ras-MAPK通路在食管癌中的研究进展木 昌毓穗 ， 刘季春 ，傅华群 ， 喻本桐 ，徐建军。， 王一明 ，魏益平 ， 邹书兵 (南昌大学 第一附属医院胸心血管外科，第二附属医院普外科， 第二附属医院胸心血管外科，江西 南昌330006) RolesofRas-MAPK signalingpathwaysinesophagealcarcinoma CttANGYusui，LIUJi—chun ，FUHua．qun ，YUBen—tong ， XUJian-jun，WANGYi—ming。，WEIYi．ping，ZOUShu—bing (DepartmentofThoracicandCardiovascularSurgery，theFirstAf~fliatedHospital，。DepartmentofGeneralSurgery， theSecondAffiliatedHospital，DepartmentofThoracicand CardiovascularSurgery，theSecond AffiliatedHospital NanchangUniversity，Nanchang330006，China．E—mail：cyscys2005@126．corn；zgblshz2005@126．corn) [ABSTRACT] Rasisbestknownfortheabilityofregulatingcellgrowth，proliferationanddifferentiation．Muta— tionsinRasareassociatedwithabnormal cellproliferation，resultingintheincidenceofallhumancancers．Mitogen—activa- tedproteinkinase(MAPK)signalingpathwaysraethemostwelldescribedpathwaysincarcinogenesis，whichhasbeeni— dentifiedas akeydownsrteam effectorinRassignalingaswellasplayingimportantrolesinprong osisoftumors．Recently， evidencehasgraduallyaccumulatedtodemonstratethatmutation in RasoraberrantexpressionofMAPK hasprofound effectsontheincidenceofesophagealcarcinoma，andapplicationsofsomechemotherapeuticdrugscannotleadtotheex— pectantfunction．FurtherunderstandingoftherelevantmolecularmechanismsofRas—MAPK singalingpathwayswillbe helpfulfordevelopmentofefficienttargetingtherapeuticapproachestothetreatmentofesophagealcancer．Inthisarticle， theadvancesofRas-MAPK singalingpathwaysinesophagealcracinomaarereviewed． [关键词] 食管肿瘤；Ras蛋白；有丝分裂原活化蛋白激酶类 ；信号通路 [KEYWORDS] Esophagealneoplasms；Rasprotein；Mitogen—activatedproteinkinases；Signalingpathway [中图分类号] R363 [文献标志码]