腺苷酸活化蛋白激酶在脂联素心血管保护效应中作用.pdfVIP

614 生理学报 Acta Physiologica Sinica, October 25, 2007, 59 (5): 614-618 综 述 腺苷酸活化蛋白激酶在脂联素心血管保护效应中的作用 李丽，吴立玲* 北京大学医学部生理与病理生理学系，教育部分子心血管重点实验室，北京 100083 摘 要：脂联素是主要由白色脂肪组织分泌的一种活性多肽，具有调节脂肪酸和葡萄糖代谢、抗炎、减轻动脉粥样硬化 等多种生物学功能，血浆脂联素含量降低参与了代谢性疾病及心血管疾病的发生、发展。腺苷酸活化蛋白激酶(AM P- activated protein kinase, AMPK)是脂联素信号通路中的关键信号分子，本文就其在脂联素心血管保护效应中的作用作一综 述，介绍脂联素改善糖、脂代谢紊乱、动脉粥样硬化、心力衰竭及心肌缺血/ 再灌注损伤作用机制的新进展。 关键词 ：脂联素；腺苷酸活化蛋白激酶；心血管保护 中图分类号：R 3 6 3 Effect of AMP-activated protein kinase on cardiovascular protection of adiponectin LI Li, WU Li-Ling* Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100083, China Abstract: Adiponectin, derived mainly from white adipose tissue, regulates glucose and fatty acid metabolism and has anti-inflamma- tory and anti-atherosclerotic properties. The decrease in plasma adiponectin concentration contributes to the development of metabolic and cardiovascular diseases. AMP-activated protein kinase (AMPK) is a serine/threonine kinase which plays an important role in regulating many cellular processes, particularly pathways involved in cellular energy status. AMPK is now recognized as a fuel gauge in mammalian cells. Adiponectin activates AMPK phosphorylation and then promotes ATP-generating pathways in heart, including glucose transport, glycolysis, and fatty acid oxidation. The recent evidence has shown that AMPK activation has an important role in the vasculature where it may exert anti-atherosclerotic effects. Phosphorylation of AMPK induced by adiponectin inhibits protein synthesis, and may be an adaptive response to pathological cardiac hypertrophy. AMPK also has a cardioprotective role against myocardial injury and apoptosis in the ischemic heart. This review will dis