金线莲提取物RM对肾血管性高血压大鼠的血压和血管紧张素_的影响_李葆华.pdfVIP

552 2006 12 15 6 Chin J Ca diovas c Rehab il M ed, Dec 2006, V ol 15 No1 6 金线莲提取物RM 对肾血管性高血压大鼠的血压及 血管紧张素Ò的影响 李葆华, 陈以旺 : : RM ( RH R) Ò ( A ng Ò) : RH R RM , ; A ng Ò: RM RHR , A ng Ò, ( P 01 05~ 01 0 1) RM 30 m in , ( P 01 01) : RM , A ng Ò : ; ; Ò : 1008- 0074 ( 2006) 06- 0552- 03 : R446 : A Effects of extract RM from Anoectochilus on blood pressure and angiotensin Òin renovascular hypertensive rats/LI Bao- hua, HEN Yi-wang/ / hinese Journal of ardiovascular Rehabilitation Medicine, 2006, 15 (6): 552 Abstract: Objective: T o obse ve the effect s of ext act RM f om A no ect ochilus on bloo d p essu e and the plasma con- cent ations of ang io tensin Ò ( A ng Ò) in enovascula hy pe t ensiv e at s ( RHR) . Methods: RH R w e e p oduced by two- kidney o ne clip metho d. M ult imedia bio lo gical signal analysis sy stem co nnected w ith ca otid a t e y intubation was used t o eco d sy stolic bloo d p essu e ( SBP) , diasto lic blo od p essu e ( DBP) and hea t ate ( H R) , befo e and afte RM w as administ ated via femo al vein1 T he plasma concent ations of Ang Òw as measu ed by adioimmunoassay. Re- sults: Ex t act R M f o m Anoecto chilus ma kedly educed SBP, DBP , HR and A ng Ò ( P 01 05~ 01 0 1) with a dose- dependent manne . Afte 30 min, the levels of SBP , DBP and H R w e e low est ( P 01 01) . onclusion: Ex- t act RM f om A no ect ochilus can low e the SBP and DBP in RH R. T he unde p essu e effects of RM in R HR may be involved in dec easing the p o ductio n of ang io tensin Ò. Authorcs address: Depa tment of Ca dio log y , Y uquan H ospital, Q ing hua U nive sit y, Beijing, 100039, China