电导率法筛选微乳处方及对其相行为的研究_陈丽华.pdfVIP

* 陈丽华, 赵小婷, 吴德智, 朱卫丰 , 管咏梅, 刘红宁(, 330004) : 探讨电导行为结合伪三元相图 备微乳, 并对其相行为进行研究 通过电导率-含水量曲线精确绘 聚山 梨酯 80-la rasol/Gemseal40-油酸 /无水乙醇 /水体系不同表面活性剂与助表面活性剂的比例(K ) 下 一系列伪三元相图, 筛选 m 微乳处方, 采用电导率稳定性染色法粒径等对微乳基本性能进行评价, 研究不同K 对微乳体系的相行为及结构类型的影 m 响 随着含水量的增加, 电导率表现为渐进的连续变化,K 为 2: 1时, 含水量( 20% 5 66. 3% ) 电导率直线上升, 含 m 水量( 66. 3% 5 74. 5% ) 电导率趋势变缓, 含水量( 5 74. 5% ) 时电导率下降, 且此时伪三元相图中微乳区最大, 备丹皮 酚微乳和雷公藤多苷微乳在高速离心无分层, 也无絮凝或药物析出, 电导率染色法粒径等性能均符合微乳特征 电 导率法能用于微乳结构的判定并反映微乳相行为的变化, 精确绘 伪三元相图筛选微乳处方 : 微乳; 电导率; 伪三元相图; 相行为; 雷公藤多苷; 丹皮酚 : R944 : A : 1001- 2494( 2011) 01- 0040- 04 Screening the P rescriptionM icroemulsion by Conductivity and the Phase Behavior * CHEN Li-hua, ZHAO X iao-ting, WU De-zh i, ZHU W e-i feng , GUAN Yong-mei, L IU H ong-ning(Key Laboratory f orM odernPreparation of TCM, M inistry of Education, Jiangxi University of TraditionalChineseM edicine, anchang 330004, China) AB STRACT: OBJECT VE To study the preparing m icroemu lsion y conductance and pseudo-ternary phase diagram, and to re- search its phase ehavior1 M ETHODS According to conductivity- moisture content graph, a series of pseudo-ternary phase d iagram a out the system of tween80-la rasol / Gem seal40-oleic acid / anhydrous ethanol / w ater under the d ifferen t proportion of su rfactant and cosurfactant(K ) accurately, screen ing m icroem ulsion prescription, evaluating asic perform ance of m icroemu lsion w ith electric m conductivity, sta ility, dyeing m ethod, drop let size, studyi