4.中国稀土药物研究进展_高锦章.pdf

( ) 38 2002 1 108 Journ l of Northwest Norm l University ( N tur l Science) Vol38 2002 No1 中国稀土药物研究进展 高锦章, 龙全江, 杨 韬* ( , 730070) : 综述了近10 年来中国在稀土药物合成和药理作用方面的研 进展及发展趋向. 研 现状反映出: 参与药物 合成的配体以杂环化合物类为主, 稀土元素以镧镨钕钐为多; 药理作用研 主要表现在抗肿瘤抗突变抗 菌抗病毒以及对消化系统和内分泌系统的影响等方面. : 稀土药物; 药物合成; 药理作用 + : TQ 462 91 : A : 1001988 ( 2002) Progress of r re e rth drugs in Chin GAO Jinzh ng, LONG Qu nji ng, YANG T o ( College of Chemistry nd Chemic l Engineering, Northwest Norm l University, L nzhou 730070, G nsu, Chin ) Abstract : This development in r re e rth drugs in Chin in the p st dec de is reviewed. The study cont ins two p rts: one is synthesis, the other is drugs ction nd mech nism of ction. The present condition of the study shows th t the lig nds which p rticip te in compounding drugs re m inly composed of heterocyclic compounds nd th t the r re e rth elements m inly re L , Pr, Nd, Sm. The study on ph rm cology is represented in the respects of ntitumor, nti mut tion, ntigerms, ntivirus, nd the influence on digestive system nd intern l system. Key words: r re e rth drugs; synthesis of drug; drug ction nd mech nism of ction 20 70 , 76%, , . . . , 1 . 配 体 稀土离子 文献 . N苯基亚氨基二乙 L , Ce, Pr, Nd, Sm, Eu, Gd, [ 1] 酸酐 Tb, Dy, Ho, Er, Yb, Se, Y 1 硫代嘧啶 L , Pr, Nd [ 2]