31例胃小间质瘤临床特点及预后分析_.pdfVIP

730 中国肿瘤临床2013年第40卷第12期 Chin J Clin Oncol 2013,Vol.40,No.12 31例胃小间质瘤临床特点及预后分析* 黄 振 李 原 赵 宏 赵建军 蔡建强 探讨原发于胃的小间质瘤的临床病理特点和预后影响因素。 回顾性分析1999年3月～2012年3月期间 摘要 目的： 方法： 在中国医学科学院肿瘤医院接受手术治疗并经病理证实的31例胃小间质瘤的临床资料，统计临床特点并分析影响其预后的因 素。 31例患者中29例获得随访（随访率93.5%）。其中男性10例，女性21例，中位年龄58（37～81）岁。腹部不适和腹痛是 结果： 最主要的首发症状（各10例，32.3%）。全组患者均接受手术治疗，胃大部切除和胃壁局部切除各11例，腹腔镜下胃壁局部切除5 例，胃镜下肿瘤剥离4例，术后无重大并发症。截止到随访终点，肿瘤复发2例，肝转移1例；因肿瘤进展死亡1例，因其他恶性肿 瘤死亡1例。中位总生存时间（OS）预测值为130.4个月，中位无疾病进展时间（PFS）预测值为120.3个月。结论：胃小间质瘤总体 预后较好；手术切除是主要治疗方式，可根据情况选取微创治疗方式；肿瘤坏死、出血和胃黏膜受累可能是预后不良因素。 关键词 胃肠道小间质瘤 外科手术 微创 预后 doi:10.3969/j.issn.1000-8179.2013.12.012 Prognostic factors and clinicopathological characteristics of small gastrointestinal stromal tumor of the stomach: A retrospective study of 31 cases Zhen HUANG, Yuan LI, Hong ZHAO, Jianjun ZHAO, Jianqiang CAI Correspondence to: Jianqiang CAI; E-mail: caijianqiang188@ Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medi- cal College, Beijing 100021, China This work was supported by the Clinical Research Special Foundation of the Wu Jieping Medical Foundation (No. 320675012622) Abstract Objective: The present study aimed to analyze the clinicopathological characteristics and prognostic factors of small gastrointestinal stromal tumors (GISTs) of the stomach. Methods: A total of 31 small gastric GIST patients, 10 males and 21 females, with a median age of 58 years old (37 ～81 years), who underwent surgery at any time from 1999 to 2012 were included in this study. The clinical records of the patients were analyzed retrospectively. Results: Abdominal discomfort and pain ( 10 cases, 32.3%, respective- l